Travel-related acquisition of diarrhoeagenic bacteria, enteral viruses and parasites in a prospective cohort of 98 Dutch travellers

Jarne M. van Hattem; Maris S. Arcilla; Martin P. Grobusch; Aldert Bart; Martin C. Bootsma; Perry J. van Genderen; Tom van Gool; Abraham Goorhuis; Jaap J. van Hellemond; Richard Molenkamp; Nicky Molhoek; Astrid M. Oude lashof; Ellen E. Stobberingh; Bob de Wever; Henri A. Verbrugh; Damian C. Melles; John Penders; Constance Schultsz; Menno D. de Jong

doi:10.1016/j.tmaid.2017.08.003

Travel-related acquisition of diarrhoeagenic bacteria, enteral viruses and parasites in a prospective cohort of 98 Dutch travellers

Jarne M. van Hattem^*, Maris S. Arcilla, Martin P. Grobusch, Aldert Bart, Martin C. Bootsma, Perry J. van Genderen, Tom van Gool, Abraham Goorhuis, Jaap J. van Hellemond, Richard Molenkamp, Nicky Molhoek, Astrid M. Oude lashof, Ellen E. Stobberingh, Bob de Wever, Henri A. Verbrugh, Damian C. Melles, John Penders, Constance Schultsz, Menno D. de Jong

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

55 Downloads (Pure)

Abstract

Background: Limited prospective data are available on the acquisition of viral, bacterial and parasitic diarrhoeagenic agents by healthy individuals during travel.

Methods: To determine the frequency of travel associated acquisition of 19 pathogens in 98 intercontinental travellers, qPCR was used to detect 8 viral pathogens, 6 bacterial enteric pathogens and 5 parasite species in faecal samples collected immediately before and after travel.

Results: We found high pre-travel carriage rates of Blastocystis spp. and Dientamoeba fragilis of 32% and 19% respectively. Pre-travel prevalences of all other tested pathogens were below 3%. Blastocystis spp. (10%), Plesiomonas shigelloides (7%), D. fragilis (6%) and Shigella spp. (5%) were the most frequently acquired pathogens and acquisition of enteral viruses and hepatitis E virus in this relatively small group of travellers was rare or non-existent.

Conclusions: Our findings suggest that the role of viruses as the cause of persisting traveller's diarrhoea is limited and bacterial pathogens are more likely as a cause of traveller's diarrhoea. The substantial proportion of travellers carrying Blastocystis spp. and D. fragilis before travel warrants cautious interpretation of positive samples in returning travellers with gastrointestinal complaints. (C) 2017 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	33-36
Number of pages	4
Journal	Travel Medicine and Infectious Disease
Volume	19
DOIs	https://doi.org/10.1016/j.tmaid.2017.08.003
Publication status	Published - Sept 2017

Keywords

Travel
Diarrhoea
Bacteria
Viruses
Parasites
Acquisition
HEPATITIS-E
INFECTION

Access to Document

10.1016/j.tmaid.2017.08.003Licence: CC BY

Full TextFinal published version, 221 KBLicence: Taverne

Cite this

van Hattem, J. M., Arcilla, M. S., Grobusch, M. P., Bart, A., Bootsma, M. C., van Genderen, P. J., van Gool, T., Goorhuis, A., van Hellemond, J. J., Molenkamp, R., Molhoek, N., lashof, A. M. O., Stobberingh, E. E., de Wever, B., Verbrugh, H. A., Melles, D. C., Penders, J., Schultsz, C., & de Jong, M. D. (2017). Travel-related acquisition of diarrhoeagenic bacteria, enteral viruses and parasites in a prospective cohort of 98 Dutch travellers. Travel Medicine and Infectious Disease, 19, 33-36. https://doi.org/10.1016/j.tmaid.2017.08.003

@article{8b3ca1f1a02c4c94a492455604f2069c,

title = "Travel-related acquisition of diarrhoeagenic bacteria, enteral viruses and parasites in a prospective cohort of 98 Dutch travellers",

abstract = "Background: Limited prospective data are available on the acquisition of viral, bacterial and parasitic diarrhoeagenic agents by healthy individuals during travel.Methods: To determine the frequency of travel associated acquisition of 19 pathogens in 98 intercontinental travellers, qPCR was used to detect 8 viral pathogens, 6 bacterial enteric pathogens and 5 parasite species in faecal samples collected immediately before and after travel.Results: We found high pre-travel carriage rates of Blastocystis spp. and Dientamoeba fragilis of 32% and 19% respectively. Pre-travel prevalences of all other tested pathogens were below 3%. Blastocystis spp. (10%), Plesiomonas shigelloides (7%), D. fragilis (6%) and Shigella spp. (5%) were the most frequently acquired pathogens and acquisition of enteral viruses and hepatitis E virus in this relatively small group of travellers was rare or non-existent.Conclusions: Our findings suggest that the role of viruses as the cause of persisting traveller's diarrhoea is limited and bacterial pathogens are more likely as a cause of traveller's diarrhoea. The substantial proportion of travellers carrying Blastocystis spp. and D. fragilis before travel warrants cautious interpretation of positive samples in returning travellers with gastrointestinal complaints. (C) 2017 Elsevier Ltd. All rights reserved.",

keywords = "Travel, Diarrhoea, Bacteria, Viruses, Parasites, Acquisition, HEPATITIS-E, INFECTION",

author = "{van Hattem}, {Jarne M.} and Arcilla, {Maris S.} and Grobusch, {Martin P.} and Aldert Bart and Bootsma, {Martin C.} and {van Genderen}, {Perry J.} and {van Gool}, Tom and Abraham Goorhuis and {van Hellemond}, {Jaap J.} and Richard Molenkamp and Nicky Molhoek and lashof, {Astrid M. Oude} and Stobberingh, {Ellen E.} and {de Wever}, Bob and Verbrugh, {Henri A.} and Melles, {Damian C.} and John Penders and Constance Schultsz and {de Jong}, {Menno D.}",

year = "2017",

month = sep,

doi = "10.1016/j.tmaid.2017.08.003",

language = "English",

volume = "19",

pages = "33--36",

journal = "Travel Medicine and Infectious Disease",

issn = "1477-8939",

publisher = "ELSEVIER SCI LTD",

}

van Hattem, JM, Arcilla, MS, Grobusch, MP, Bart, A, Bootsma, MC, van Genderen, PJ, van Gool, T, Goorhuis, A, van Hellemond, JJ, Molenkamp, R, Molhoek, N, lashof, AMO, Stobberingh, EE, de Wever, B, Verbrugh, HA, Melles, DC, Penders, J, Schultsz, C & de Jong, MD 2017, 'Travel-related acquisition of diarrhoeagenic bacteria, enteral viruses and parasites in a prospective cohort of 98 Dutch travellers', Travel Medicine and Infectious Disease, vol. 19, pp. 33-36. https://doi.org/10.1016/j.tmaid.2017.08.003

TY - JOUR

T1 - Travel-related acquisition of diarrhoeagenic bacteria, enteral viruses and parasites in a prospective cohort of 98 Dutch travellers

AU - van Hattem, Jarne M.

AU - Arcilla, Maris S.

AU - Grobusch, Martin P.

AU - Bart, Aldert

AU - Bootsma, Martin C.

AU - van Genderen, Perry J.

AU - van Gool, Tom

AU - Goorhuis, Abraham

AU - van Hellemond, Jaap J.

AU - Molenkamp, Richard

AU - Molhoek, Nicky

AU - lashof, Astrid M. Oude

AU - Stobberingh, Ellen E.

AU - de Wever, Bob

AU - Verbrugh, Henri A.

AU - Melles, Damian C.

AU - Penders, John

AU - Schultsz, Constance

AU - de Jong, Menno D.

PY - 2017/9

Y1 - 2017/9

N2 - Background: Limited prospective data are available on the acquisition of viral, bacterial and parasitic diarrhoeagenic agents by healthy individuals during travel.Methods: To determine the frequency of travel associated acquisition of 19 pathogens in 98 intercontinental travellers, qPCR was used to detect 8 viral pathogens, 6 bacterial enteric pathogens and 5 parasite species in faecal samples collected immediately before and after travel.Results: We found high pre-travel carriage rates of Blastocystis spp. and Dientamoeba fragilis of 32% and 19% respectively. Pre-travel prevalences of all other tested pathogens were below 3%. Blastocystis spp. (10%), Plesiomonas shigelloides (7%), D. fragilis (6%) and Shigella spp. (5%) were the most frequently acquired pathogens and acquisition of enteral viruses and hepatitis E virus in this relatively small group of travellers was rare or non-existent.Conclusions: Our findings suggest that the role of viruses as the cause of persisting traveller's diarrhoea is limited and bacterial pathogens are more likely as a cause of traveller's diarrhoea. The substantial proportion of travellers carrying Blastocystis spp. and D. fragilis before travel warrants cautious interpretation of positive samples in returning travellers with gastrointestinal complaints. (C) 2017 Elsevier Ltd. All rights reserved.

AB - Background: Limited prospective data are available on the acquisition of viral, bacterial and parasitic diarrhoeagenic agents by healthy individuals during travel.Methods: To determine the frequency of travel associated acquisition of 19 pathogens in 98 intercontinental travellers, qPCR was used to detect 8 viral pathogens, 6 bacterial enteric pathogens and 5 parasite species in faecal samples collected immediately before and after travel.Results: We found high pre-travel carriage rates of Blastocystis spp. and Dientamoeba fragilis of 32% and 19% respectively. Pre-travel prevalences of all other tested pathogens were below 3%. Blastocystis spp. (10%), Plesiomonas shigelloides (7%), D. fragilis (6%) and Shigella spp. (5%) were the most frequently acquired pathogens and acquisition of enteral viruses and hepatitis E virus in this relatively small group of travellers was rare or non-existent.Conclusions: Our findings suggest that the role of viruses as the cause of persisting traveller's diarrhoea is limited and bacterial pathogens are more likely as a cause of traveller's diarrhoea. The substantial proportion of travellers carrying Blastocystis spp. and D. fragilis before travel warrants cautious interpretation of positive samples in returning travellers with gastrointestinal complaints. (C) 2017 Elsevier Ltd. All rights reserved.

KW - Travel

KW - Diarrhoea

KW - Bacteria

KW - Viruses

KW - Parasites

KW - Acquisition

KW - HEPATITIS-E

KW - INFECTION

U2 - 10.1016/j.tmaid.2017.08.003

DO - 10.1016/j.tmaid.2017.08.003

M3 - Article

C2 - 28842214

SN - 1477-8939

VL - 19

SP - 33

EP - 36

JO - Travel Medicine and Infectious Disease

JF - Travel Medicine and Infectious Disease

ER -