Traumatic stress and accelerated DNA methylation age: A meta-analysis

Erika J. Wolf; Hannah Maniates; Nicole Nugent; Adam X. Maihofer; Don Armstrong; Andrew Ratanatharathorn; Allison E. Ashley-Koch; Melanie Garrett; Nathan A. Kimbrel; Adriana Lori; Allison E. Aiello; Dewleen G. Baker; Jean C. Beckham; Marco P. Boks; Sandro Galea; Elbert Geuze; Michael A. Hauser; Ronald C. Kessler; Karestan C. Koenen; Mark W. Miller; Kerry J. Ressler; Victoria Risbrough; Bart P. P. Rutten; Murray B. Stein; Robert J. Ursano; Eric Vermetten; Christiaan H. Vinkers; Monica Uddin; Alicia K. Smith; Caroline M. Nievergelt; Mark W. Logue; VA Mid-Atlantic MIRECC Workgroup

doi:10.1016/j.psyneuen.2017.12.007

Traumatic stress and accelerated DNA methylation age: A meta-analysis

Erika J. Wolf^*, Hannah Maniates, Nicole Nugent, Adam X. Maihofer, Don Armstrong, Andrew Ratanatharathorn, Allison E. Ashley-Koch, Melanie Garrett, Nathan A. Kimbrel, Adriana Lori, Allison E. Aiello, Dewleen G. Baker, Jean C. Beckham, Marco P. Boks, Sandro Galea, Elbert Geuze, Michael A. Hauser, Ronald C. Kessler, Karestan C. Koenen, Mark W. MillerKerry J. Ressler, Victoria Risbrough, Bart P. P. Rutten, Murray B. Stein, Robert J. Ursano, Eric Vermetten, Christiaan H. Vinkers, Monica Uddin, Alicia K. Smith, Caroline M. Nievergelt, Mark W. Logue, VA Mid-Atlantic MIRECC Workgroup

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

92 Citations (Web of Science)

Original language	English
Pages (from-to)	123-134
Number of pages	12
Journal	Psychoneuroendocrinology
Volume	92
DOIs	https://doi.org/10.1016/j.psyneuen.2017.12.007
Publication status	Published - 1 Jun 2018

Keywords

DNA methylation
Traumatic stress
PTSD
Accelerated aging
Meta-analysis
Epigenetic clock
GENOME-WIDE ASSOCIATION
INTERNATIONAL DIAGNOSTIC INTERVIEW
INDIVIDUAL PARTICIPANT DATA
EPIGENETIC CLOCK ANALYSIS
PSYCHOMETRIC PROPERTIES
TELOMERE LENGTH
CORTICAL THICKNESS
MENTAL-HEALTH
PATIENT DATA
DISORDER
RESILIENCE
INVENTORY
Epigenesis, Genetic
Humans
Middle Aged
Male
DNA Methylation
Stress Disorders, Post-Traumatic/genetics
Adult
Female
Genetic Predisposition to Disease
Trauma Severity Indices
Cohort Studies

Access to Document

10.1016/j.psyneuen.2017.12.007

Cite this

Wolf, E. J., Maniates, H., Nugent, N., Maihofer, A. X., Armstrong, D., Ratanatharathorn, A., Ashley-Koch, A. E., Garrett, M., Kimbrel, N. A., Lori, A., Aiello, A. E., Baker, D. G., Beckham, J. C., Boks, M. P., Galea, S., Geuze, E., Hauser, M. A., Kessler, R. C., Koenen, K. C., ... VA Mid-Atlantic MIRECC Workgroup (2018). Traumatic stress and accelerated DNA methylation age: A meta-analysis. Psychoneuroendocrinology, 92, 123-134. https://doi.org/10.1016/j.psyneuen.2017.12.007

Wolf, Erika J. ; Maniates, Hannah ; Nugent, Nicole ; Maihofer, Adam X. ; Armstrong, Don ; Ratanatharathorn, Andrew ; Ashley-Koch, Allison E. ; Garrett, Melanie ; Kimbrel, Nathan A. ; Lori, Adriana ; Aiello, Allison E. ; Baker, Dewleen G. ; Beckham, Jean C. ; Boks, Marco P. ; Galea, Sandro ; Geuze, Elbert ; Hauser, Michael A. ; Kessler, Ronald C. ; Koenen, Karestan C. ; Miller, Mark W. ; Ressler, Kerry J. ; Risbrough, Victoria ; Rutten, Bart P. P. ; Stein, Murray B. ; Ursano, Robert J. ; Vermetten, Eric ; Vinkers, Christiaan H. ; Uddin, Monica ; Smith, Alicia K. ; Nievergelt, Caroline M. ; Logue, Mark W. ; VA Mid-Atlantic MIRECC Workgroup. / Traumatic stress and accelerated DNA methylation age: A meta-analysis. In: Psychoneuroendocrinology. 2018 ; Vol. 92. pp. 123-134.

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title = "Traumatic stress and accelerated DNA methylation age: A meta-analysis",

keywords = "DNA methylation, Traumatic stress, PTSD, Accelerated aging, Meta-analysis, Epigenetic clock, GENOME-WIDE ASSOCIATION, INTERNATIONAL DIAGNOSTIC INTERVIEW, INDIVIDUAL PARTICIPANT DATA, EPIGENETIC CLOCK ANALYSIS, PSYCHOMETRIC PROPERTIES, TELOMERE LENGTH, CORTICAL THICKNESS, MENTAL-HEALTH, PATIENT DATA, DISORDER, RESILIENCE, INVENTORY, Epigenesis, Genetic, Humans, Middle Aged, Male, DNA Methylation, Stress Disorders, Post-Traumatic/genetics, Adult, Female, Genetic Predisposition to Disease, Trauma Severity Indices, Cohort Studies",

author = "Wolf, {Erika J.} and Hannah Maniates and Nicole Nugent and Maihofer, {Adam X.} and Don Armstrong and Andrew Ratanatharathorn and Ashley-Koch, {Allison E.} and Melanie Garrett and Kimbrel, {Nathan A.} and Adriana Lori and Aiello, {Allison E.} and Baker, {Dewleen G.} and Beckham, {Jean C.} and Boks, {Marco P.} and Sandro Galea and Elbert Geuze and Hauser, {Michael A.} and Kessler, {Ronald C.} and Koenen, {Karestan C.} and Miller, {Mark W.} and Ressler, {Kerry J.} and Victoria Risbrough and Rutten, {Bart P. P.} and Stein, {Murray B.} and Ursano, {Robert J.} and Eric Vermetten and Vinkers, {Christiaan H.} and Monica Uddin and Smith, {Alicia K.} and Nievergelt, {Caroline M.} and Logue, {Mark W.} and {VA Mid-Atlantic MIRECC Workgroup}",

year = "2018",

month = jun,

day = "1",

doi = "10.1016/j.psyneuen.2017.12.007",

language = "English",

volume = "92",

pages = "123--134",

journal = "Psychoneuroendocrinology",

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Wolf, EJ, Maniates, H, Nugent, N, Maihofer, AX, Armstrong, D, Ratanatharathorn, A, Ashley-Koch, AE, Garrett, M, Kimbrel, NA, Lori, A, Aiello, AE, Baker, DG, Beckham, JC, Boks, MP, Galea, S, Geuze, E, Hauser, MA, Kessler, RC, Koenen, KC, Miller, MW, Ressler, KJ, Risbrough, V, Rutten, BPP, Stein, MB, Ursano, RJ, Vermetten, E, Vinkers, CH, Uddin, M, Smith, AK, Nievergelt, CM, Logue, MW & VA Mid-Atlantic MIRECC Workgroup 2018, 'Traumatic stress and accelerated DNA methylation age: A meta-analysis', Psychoneuroendocrinology, vol. 92, pp. 123-134. https://doi.org/10.1016/j.psyneuen.2017.12.007

Traumatic stress and accelerated DNA methylation age: A meta-analysis. / Wolf, Erika J.; Maniates, Hannah; Nugent, Nicole; Maihofer, Adam X.; Armstrong, Don; Ratanatharathorn, Andrew; Ashley-Koch, Allison E.; Garrett, Melanie; Kimbrel, Nathan A.; Lori, Adriana; Aiello, Allison E.; Baker, Dewleen G.; Beckham, Jean C.; Boks, Marco P.; Galea, Sandro; Geuze, Elbert; Hauser, Michael A.; Kessler, Ronald C.; Koenen, Karestan C.; Miller, Mark W.; Ressler, Kerry J.; Risbrough, Victoria; Rutten, Bart P. P.; Stein, Murray B.; Ursano, Robert J.; Vermetten, Eric; Vinkers, Christiaan H.; Uddin, Monica; Smith, Alicia K.; Nievergelt, Caroline M.; Logue, Mark W.; VA Mid-Atlantic MIRECC Workgroup.

In: Psychoneuroendocrinology, Vol. 92, 01.06.2018, p. 123-134.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Traumatic stress and accelerated DNA methylation age: A meta-analysis

AU - Wolf, Erika J.

AU - Maniates, Hannah

AU - Nugent, Nicole

AU - Maihofer, Adam X.

AU - Armstrong, Don

AU - Ratanatharathorn, Andrew

AU - Ashley-Koch, Allison E.

AU - Garrett, Melanie

AU - Kimbrel, Nathan A.

AU - Lori, Adriana

AU - Aiello, Allison E.

AU - Baker, Dewleen G.

AU - Beckham, Jean C.

AU - Boks, Marco P.

AU - Galea, Sandro

AU - Geuze, Elbert

AU - Hauser, Michael A.

AU - Kessler, Ronald C.

AU - Koenen, Karestan C.

AU - Miller, Mark W.

AU - Ressler, Kerry J.

AU - Risbrough, Victoria

AU - Rutten, Bart P. P.

AU - Stein, Murray B.

AU - Ursano, Robert J.

AU - Vermetten, Eric

AU - Vinkers, Christiaan H.

AU - Uddin, Monica

AU - Smith, Alicia K.

AU - Nievergelt, Caroline M.

AU - Logue, Mark W.

AU - VA Mid-Atlantic MIRECC Workgroup

PY - 2018/6/1

Y1 - 2018/6/1

KW - DNA methylation

KW - Traumatic stress

KW - PTSD

KW - Accelerated aging

KW - Meta-analysis

KW - Epigenetic clock

KW - GENOME-WIDE ASSOCIATION

KW - INTERNATIONAL DIAGNOSTIC INTERVIEW

KW - INDIVIDUAL PARTICIPANT DATA

KW - EPIGENETIC CLOCK ANALYSIS

KW - PSYCHOMETRIC PROPERTIES

KW - TELOMERE LENGTH

KW - CORTICAL THICKNESS

KW - MENTAL-HEALTH

KW - PATIENT DATA

KW - DISORDER

KW - RESILIENCE

KW - INVENTORY

KW - Epigenesis, Genetic

KW - Humans

KW - Middle Aged

KW - Male

KW - DNA Methylation

KW - Stress Disorders, Post-Traumatic/genetics

KW - Adult

KW - Female

KW - Genetic Predisposition to Disease

KW - Trauma Severity Indices

KW - Cohort Studies

U2 - 10.1016/j.psyneuen.2017.12.007

DO - 10.1016/j.psyneuen.2017.12.007

M3 - Article

C2 - 29452766

VL - 92

SP - 123

EP - 134

JO - Psychoneuroendocrinology

JF - Psychoneuroendocrinology

SN - 0306-4530

ER -