Translational considerations for the design of untethered nanomaterials in human neural stimulation

D. Dominguez-Paredes, A. Jahanshahi, K.L. Kozielski*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Web of Science)

Abstract

Neural stimulation is a powerful tool to study brain physiology and an effective treatment for many neurological disorders. Conventional interfaces use electrodes implanted in the brain. As these are often invasive and have limited spatial targeting, they carry a potential risk of side-effects. Smaller neural devices may overcome these obstacles, and as such, the field of nanoscale and remotely powered neural stimulation devices is growing. This review will report on current untethered, injectable nanomaterial technologies intended for neural stimulation, with a focus on material-tissue interface engineering. We will review nanomaterials capable of wireless neural stimulation, and discuss their stimulation mechanisms. Taking cues from more established nanomaterial fields (e.g., cancer theranostics, drug delivery), we will then discuss methods to modify material interfaces with passive and bioactive coatings. We will discuss methods of delivery to a desired brain region, particularly in the context of how delivery and localization are affected by surface modification. We will also consider each of these aspects of nanoscale neurostimulators with a focus on their prospects for translation to clinical use. (c) 2021 Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http:// creativecommons.org/licenses/by-nc-nd/4.0/).
Original languageEnglish
Pages (from-to)1285-1297
Number of pages13
JournalBrain stimulation
Volume14
Issue number5
DOIs
Publication statusPublished - 1 Sep 2021

Keywords

  • Nanomaterials
  • Neural stimulation
  • Surface modification
  • Clinical translation
  • IRON-OXIDE NANOPARTICLES
  • DEEP BRAIN-STIMULATION
  • TRANSCRANIAL MAGNETIC STIMULATION
  • MULTIWALL CARBON NANOTUBES
  • BORON-NITRIDE NANOTUBES
  • CENTRAL-NERVOUS-SYSTEM
  • GOLD NANORODS
  • INORGANIC NANOPARTICLES
  • COLLOIDAL STABILITY
  • LIVING CELLS

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