Transition metal-catalysed carbene- and nitrene transfer to carbon monoxide and isocyanides

T.R. Roose, D.S. Verdoorn, P. Mampuys, E. Ruijter*, B.U.W. Maes*, R.V.A. Orru*

*Corresponding author for this work

Research output: Contribution to journal(Systematic) Review article peer-review

Abstract

Transition metal-catalysed carbene- and nitrene transfer to the C1-building blocks carbon monoxide and isocyanides provides heteroallenes (i.e. ketenes, isocyanates, ketenimines and carbodiimides). These are versatile and reactive compounds allowing in situ transformation towards numerous functional groups and organic compounds, including heterocycles. Both one-pot and tandem processes have been developed providing valuable synthetic methods for the organic chemistry toolbox. This review discusses all known transition metal-catalysed carbene- and nitrene transfer reactions towards carbon monoxide and isocyanides and in situ transformation of the heteroallenes hereby obtained, with a special focus on the general mechanistic considerations.
Original languageEnglish
Pages (from-to)5842-5877
Number of pages36
JournalChemical Society Reviews
Volume51
Issue number14
Early online date1 Jun 2022
DOIs
Publication statusPublished - 18 Jul 2022

Keywords

  • C-H ACTIVATION
  • INSERTION REACTIONS
  • SULFONYL AZIDES
  • ORGANIC-SYNTHESIS
  • CARBONYLATION REACTIONS
  • 3-COMPONENT REACTION
  • MIGRATORY INSERTION
  • DIAZO-COMPOUNDS
  • COBALT-CARBENE
  • PALLADIUM

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