Transgenic short-QT syndrome 1 rabbits mimic the human disease phenotype with QT/action potential duration shortening in the atria and ventricles and increased ventricular tachycardia/ventricular fibrillation inducibility

Katja E. Odening*, Ilona Bodi, Gerlind Franke, Raphaela Rieke, Anna Ryan de Medeiros, Stefanie Perez-Feliz, Hannah Fuerniss, Lea Mettke, Konstantin Michaelides, Corinna N. Lang, Johannes Steinfurt, Naga Deepa Pantulu, David Ziupa, Marius Menza, Manfred Zehender, Heiko Bugger, Remi Peyronnet, Jan C. Behrends, Zoltan Doleschall, Axel Zur HausenChristoph Bode, Genevieve Jolivet, Michael Brunner

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Pages (from-to)842-853
Number of pages12
JournalEuropean Heart Journal
Volume40
Issue number10
DOIs
Publication statusPublished - 7 Mar 2019

Keywords

  • Short-QT syndrome
  • Animal models
  • Cardiac repolarization
  • Ion channels
  • Electrical remodelling
  • Arrhythmia
  • SUDDEN-DEATH
  • MUTATION

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