Transgenic Rat Models of Huntington's Disease

João Casaca Carreira, Ali Jahanshahi, Dagmar Zeef, Ersoy Kocabicak, Rinske Vlamings, Stephan von Hörsten, Yasin Temel

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

2 Citations (Scopus)

Abstract

Several animal models for Huntington's disease (HD) have been created in order to investigate mechanisms of disease, and to evaluate the potency of novel therapies. Here, we describe the characteristics of the two transgenic rat models: transgenic rat model of HD (fragment model) and the Bacterial Artificial Chromosome HD model (full-length model). We discuss their genetic, behavioural, neuropathological and neurophysiological features.

Original languageEnglish
Title of host publicationBehavioral Neurobiology of Huntington's Disease and Parkinson's Disease
EditorsHoa Huu Phuc Nguyen, M. Angela Cenci
Pages135-47
Number of pages13
Volume22
DOIs
Publication statusPublished - 2015

Publication series

SeriesCurrent Topics in Behavioral Neurosciences
Volume22

Keywords

  • Animals
  • Disease Models, Animal
  • Huntington Disease
  • Rats
  • Rats, Transgenic

Cite this

Carreira, J. C., Jahanshahi, A., Zeef, D., Kocabicak, E., Vlamings, R., von Hörsten, S., & Temel, Y. (2015). Transgenic Rat Models of Huntington's Disease. In H. Huu Phuc Nguyen, & M. A. Cenci (Eds.), Behavioral Neurobiology of Huntington's Disease and Parkinson's Disease (Vol. 22, pp. 135-47). Current Topics in Behavioral Neurosciences, Vol.. 22 https://doi.org/10.1007/7854_2013_245