Transgenerational occurrence of allergic disease and autoimmunity: general practice-based epidemiological research

T. Maas, C. Nieuwhof, V. Lima Passos, C. Robertson, A. Boonen, R.B. Landewé, J.W. Voncken, J.A. Knottnerus, J.G. Damoiseaux

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)

Abstract

Background: Corresponding with the T helper cell type 1/T helper cell type 2 hypothesis, autoimmune and allergic diseases are considered pathologically distinct and mutually exclusive conditions. Co-occurrence of autoimmune disorders and allergy within patients, however, has been reported. Transgenerational co-occurrence of autoimmune and allergic disease has been less often described and may differ from the intra-patient results..

Aims: To test the hypothesis that autoimmune disorders in parents are a risk factor for the development of an allergic disease in their offspring.

Methods: Prospectively registered (by academic general practitioners) International Classifications of Primary Care (ICPC) for diagnoses of autoimmune disorders and allergy within families were evaluated (n=5,604 families) by performing multiple logistic regression analyses.

Results: The presence of any ICPC-encoded autoimmune disorder in fathers appeared to be associated with an increased risk in their eldest children of developing an allergy (odds ratio (OR) 1.4, 95% Cl 1.042 to 1.794). Psoriasis in fathers was particularly shown to be of influence (OR 1.5, 95% CI 1.061 to 2.117) and, although any ICPC-encoded autoimmune disease in mothers was found not to be of significance, the combined international code for registering rheumatoid arthritis/ankylosing spondylitis in mothers was OR 1.7 (95% Cl 1.031 to 2.852).

Conclusions: The occurrence of ICPC-encoded autoimmune disorders in parents, especially psoriasis and rheumatoid arthritis/ankylosing spondylitis, significantly increases the occurrence of allergic disease in their children. After validation in follow-up research in a larger sample, these results may lead to the inclusion of 'parental autoimmune condition' as a risk factor in the general practitioner's diagnostics of allergic disease. (C) 2013 Primary Care Respiratory Society UK. All rights reserved.

Original languageEnglish
Pages (from-to)14-21
Number of pages8
JournalPrimary Care Respiratory Journal
Volume23
Issue number1
DOIs
Publication statusPublished - Mar 2014

Keywords

  • allergy
  • asthma
  • diagnosis
  • environmental
  • epidemiology
  • guideline
  • primary care
  • survey
  • INFLAMMATORY-BOWEL-DISEASE
  • RHEUMATOID-ARTHRITIS
  • ANKYLOSING-SPONDYLITIS
  • RISK-FACTORS
  • ASTHMA
  • EPIGENETICS
  • POPULATION
  • ASSOCIATIONS
  • ENVIRONMENT
  • HYPOTHESIS

Cite this

@article{6a1032b48fdc4712a70be989a757027d,
title = "Transgenerational occurrence of allergic disease and autoimmunity: general practice-based epidemiological research",
abstract = "Background: Corresponding with the T helper cell type 1/T helper cell type 2 hypothesis, autoimmune and allergic diseases are considered pathologically distinct and mutually exclusive conditions. Co-occurrence of autoimmune disorders and allergy within patients, however, has been reported. Transgenerational co-occurrence of autoimmune and allergic disease has been less often described and may differ from the intra-patient results..Aims: To test the hypothesis that autoimmune disorders in parents are a risk factor for the development of an allergic disease in their offspring.Methods: Prospectively registered (by academic general practitioners) International Classifications of Primary Care (ICPC) for diagnoses of autoimmune disorders and allergy within families were evaluated (n=5,604 families) by performing multiple logistic regression analyses.Results: The presence of any ICPC-encoded autoimmune disorder in fathers appeared to be associated with an increased risk in their eldest children of developing an allergy (odds ratio (OR) 1.4, 95{\%} Cl 1.042 to 1.794). Psoriasis in fathers was particularly shown to be of influence (OR 1.5, 95{\%} CI 1.061 to 2.117) and, although any ICPC-encoded autoimmune disease in mothers was found not to be of significance, the combined international code for registering rheumatoid arthritis/ankylosing spondylitis in mothers was OR 1.7 (95{\%} Cl 1.031 to 2.852).Conclusions: The occurrence of ICPC-encoded autoimmune disorders in parents, especially psoriasis and rheumatoid arthritis/ankylosing spondylitis, significantly increases the occurrence of allergic disease in their children. After validation in follow-up research in a larger sample, these results may lead to the inclusion of 'parental autoimmune condition' as a risk factor in the general practitioner's diagnostics of allergic disease. (C) 2013 Primary Care Respiratory Society UK. All rights reserved.",
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author = "T. Maas and C. Nieuwhof and {Lima Passos}, V. and C. Robertson and A. Boonen and R.B. Landew{\'e} and J.W. Voncken and J.A. Knottnerus and J.G. Damoiseaux",
year = "2014",
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doi = "10.4104/pcrj.2013.00108",
language = "English",
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Transgenerational occurrence of allergic disease and autoimmunity: general practice-based epidemiological research. / Maas, T.; Nieuwhof, C.; Lima Passos, V.; Robertson, C.; Boonen, A.; Landewé, R.B.; Voncken, J.W.; Knottnerus, J.A.; Damoiseaux, J.G.

In: Primary Care Respiratory Journal, Vol. 23, No. 1, 03.2014, p. 14-21.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Transgenerational occurrence of allergic disease and autoimmunity: general practice-based epidemiological research

AU - Maas, T.

AU - Nieuwhof, C.

AU - Lima Passos, V.

AU - Robertson, C.

AU - Boonen, A.

AU - Landewé, R.B.

AU - Voncken, J.W.

AU - Knottnerus, J.A.

AU - Damoiseaux, J.G.

PY - 2014/3

Y1 - 2014/3

N2 - Background: Corresponding with the T helper cell type 1/T helper cell type 2 hypothesis, autoimmune and allergic diseases are considered pathologically distinct and mutually exclusive conditions. Co-occurrence of autoimmune disorders and allergy within patients, however, has been reported. Transgenerational co-occurrence of autoimmune and allergic disease has been less often described and may differ from the intra-patient results..Aims: To test the hypothesis that autoimmune disorders in parents are a risk factor for the development of an allergic disease in their offspring.Methods: Prospectively registered (by academic general practitioners) International Classifications of Primary Care (ICPC) for diagnoses of autoimmune disorders and allergy within families were evaluated (n=5,604 families) by performing multiple logistic regression analyses.Results: The presence of any ICPC-encoded autoimmune disorder in fathers appeared to be associated with an increased risk in their eldest children of developing an allergy (odds ratio (OR) 1.4, 95% Cl 1.042 to 1.794). Psoriasis in fathers was particularly shown to be of influence (OR 1.5, 95% CI 1.061 to 2.117) and, although any ICPC-encoded autoimmune disease in mothers was found not to be of significance, the combined international code for registering rheumatoid arthritis/ankylosing spondylitis in mothers was OR 1.7 (95% Cl 1.031 to 2.852).Conclusions: The occurrence of ICPC-encoded autoimmune disorders in parents, especially psoriasis and rheumatoid arthritis/ankylosing spondylitis, significantly increases the occurrence of allergic disease in their children. After validation in follow-up research in a larger sample, these results may lead to the inclusion of 'parental autoimmune condition' as a risk factor in the general practitioner's diagnostics of allergic disease. (C) 2013 Primary Care Respiratory Society UK. All rights reserved.

AB - Background: Corresponding with the T helper cell type 1/T helper cell type 2 hypothesis, autoimmune and allergic diseases are considered pathologically distinct and mutually exclusive conditions. Co-occurrence of autoimmune disorders and allergy within patients, however, has been reported. Transgenerational co-occurrence of autoimmune and allergic disease has been less often described and may differ from the intra-patient results..Aims: To test the hypothesis that autoimmune disorders in parents are a risk factor for the development of an allergic disease in their offspring.Methods: Prospectively registered (by academic general practitioners) International Classifications of Primary Care (ICPC) for diagnoses of autoimmune disorders and allergy within families were evaluated (n=5,604 families) by performing multiple logistic regression analyses.Results: The presence of any ICPC-encoded autoimmune disorder in fathers appeared to be associated with an increased risk in their eldest children of developing an allergy (odds ratio (OR) 1.4, 95% Cl 1.042 to 1.794). Psoriasis in fathers was particularly shown to be of influence (OR 1.5, 95% CI 1.061 to 2.117) and, although any ICPC-encoded autoimmune disease in mothers was found not to be of significance, the combined international code for registering rheumatoid arthritis/ankylosing spondylitis in mothers was OR 1.7 (95% Cl 1.031 to 2.852).Conclusions: The occurrence of ICPC-encoded autoimmune disorders in parents, especially psoriasis and rheumatoid arthritis/ankylosing spondylitis, significantly increases the occurrence of allergic disease in their children. After validation in follow-up research in a larger sample, these results may lead to the inclusion of 'parental autoimmune condition' as a risk factor in the general practitioner's diagnostics of allergic disease. (C) 2013 Primary Care Respiratory Society UK. All rights reserved.

KW - allergy

KW - asthma

KW - diagnosis

KW - environmental

KW - epidemiology

KW - guideline

KW - primary care

KW - survey

KW - INFLAMMATORY-BOWEL-DISEASE

KW - RHEUMATOID-ARTHRITIS

KW - ANKYLOSING-SPONDYLITIS

KW - RISK-FACTORS

KW - ASTHMA

KW - EPIGENETICS

KW - POPULATION

KW - ASSOCIATIONS

KW - ENVIRONMENT

KW - HYPOTHESIS

U2 - 10.4104/pcrj.2013.00108

DO - 10.4104/pcrj.2013.00108

M3 - Article

VL - 23

SP - 14

EP - 21

JO - Primary Care Respiratory Journal

JF - Primary Care Respiratory Journal

SN - 1471-4418

IS - 1

ER -