Transependymal Cerebrospinal Fluid Flow: Opportunity for Drug Delivery?

Joao Casaca-Carreira, Yasin Temel, Sarah-Anna Hescham, Ali Jahanshahi*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

17 Citations (Web of Science)

Abstract

Drug delivery to the central nervous system (CNS) is complicated by the blood-brain barrier. As a result, many agents that are found to be potentially effective at their site of action cannot be sufficiently or effectively delivered to the CNS and therefore have been discarded and not developed further for clinical use, leaving many CNS diseases untreated. One way to overcome this obstacle is intracerebroventricular (ICV) delivery of the therapeutics directly to cerebrospinal fluid (CSF). Recent experimental and clinical findings reveal that CSF flows from the ventricles throughout the parenchyma towards the subarachnoid space also named minor CSF pathway, while earlier, it was suggested that only in pathological conditions such as hydrocephalus this form of CSF flow occurs. This transependymal flow of CSF provides a route to distribute ICV-infused drugs throughout the brain. More insight on transependymal CSF flow will direct more rational to ICV drug delivery and broaden its clinical indications in managing CNS diseases.
Original languageEnglish
Pages (from-to)2780-2788
Number of pages9
JournalMolecular Neurobiology
Volume55
Issue number4
DOIs
Publication statusPublished - 1 Apr 2018

Keywords

  • Cerebrospinal fluid
  • Intracerebroventricular drug delivery
  • Ependyma
  • Transependymal CSF flow
  • NORMAL-PRESSURE HYDROCEPHALUS
  • COMMUNICATING HYDROCEPHALUS
  • OBSTRUCTIVE HYDROCEPHALUS
  • HUNTINGTONS-DISEASE
  • BRAIN
  • CSF
  • DYNAMICS
  • ABSORPTION
  • PHARMACOKINETICS
  • PENETRATION

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