Trans-Resveratrol Supplementation and Endothelial Function during the Fasting and Postprandial Phase: A Randomized Placebo-Controlled Trial in Overweight and Slightly Obese Participants

Sanne M. van der Made, Jogchum Plat, Ronald P. Mensink*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Studies on the effects of the long-term intake of trans-resveratrol on vascular function are conflicting. In addition, postprandial effects of long-term trans-resveratrol intake on endothelial function are not known. We therefore supplemented 45 overweight and slightly obese volunteers (25 men and 20 women) with a mean (+/- SD) age of 61 +/- 7 years and body mass index of 28.3 +/- 3.2 kg/m(2) in random order trans-resveratrol (2 x 75 mg/day) or placebo capsules for 4 weeks, separated by a washout period of at least 4 weeks. At the end of each intervention period, brachial artery flow-mediated vasodilation (FMD) was measured before and after meal consumption. Plasma biomarkers for endothelial function, inflammation, and glucose and lipid metabolism were also determined. Compared with the placebo, trans-resveratrol did not affect fasting FMD (2.9 +/- 1.4% vs. 3.0 +/- 1.9%; p = 0.69). After the postprandial test, changes in FMD (0.7 +/- 2.3% vs. 0.2 +/- 2.6%; p = 0.13) were also not significantly different. Postprandial changes in biomarkers were also comparable. In conclusion, for overweight and slightly obese volunteers, a daily intake of 150 mg of trans-resveratrol for 4 weeks does not change plasma biomarkers of endothelial function or inflammation in the fasting state or postprandial phase.

Original languageEnglish
Article number596
Number of pages12
JournalNutrients
Volume9
Issue number6
DOIs
Publication statusPublished - Jun 2017

Keywords

  • flow-mediated vasodilation
  • vascular function
  • trans-resveratrol
  • postprandial
  • humans
  • PULSE-WAVE VELOCITY
  • HIGH-FAT MEAL
  • PRIMARY PREVENTION
  • METABOLIC PROFILE
  • OXIDATIVE STRESS
  • HEALTHY-SUBJECTS
  • BRACHIAL-ARTERY
  • GENE-EXPRESSION
  • CLINICAL-TRIAL
  • TNF-ALPHA

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