Abstract
Studies on the effects of the long-term intake of trans-resveratrol on vascular function are conflicting. In addition, postprandial effects of long-term trans-resveratrol intake on endothelial function are not known. We therefore supplemented 45 overweight and slightly obese volunteers (25 men and 20 women) with a mean (+/- SD) age of 61 +/- 7 years and body mass index of 28.3 +/- 3.2 kg/m(2) in random order trans-resveratrol (2 x 75 mg/day) or placebo capsules for 4 weeks, separated by a washout period of at least 4 weeks. At the end of each intervention period, brachial artery flow-mediated vasodilation (FMD) was measured before and after meal consumption. Plasma biomarkers for endothelial function, inflammation, and glucose and lipid metabolism were also determined. Compared with the placebo, trans-resveratrol did not affect fasting FMD (2.9 +/- 1.4% vs. 3.0 +/- 1.9%; p = 0.69). After the postprandial test, changes in FMD (0.7 +/- 2.3% vs. 0.2 +/- 2.6%; p = 0.13) were also not significantly different. Postprandial changes in biomarkers were also comparable. In conclusion, for overweight and slightly obese volunteers, a daily intake of 150 mg of trans-resveratrol for 4 weeks does not change plasma biomarkers of endothelial function or inflammation in the fasting state or postprandial phase.
Original language | English |
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Article number | 596 |
Number of pages | 12 |
Journal | Nutrients |
Volume | 9 |
Issue number | 6 |
DOIs | |
Publication status | Published - Jun 2017 |
Keywords
- flow-mediated vasodilation
- vascular function
- trans-resveratrol
- postprandial
- humans
- PULSE-WAVE VELOCITY
- HIGH-FAT MEAL
- PRIMARY PREVENTION
- METABOLIC PROFILE
- OXIDATIVE STRESS
- HEALTHY-SUBJECTS
- BRACHIAL-ARTERY
- GENE-EXPRESSION
- CLINICAL-TRIAL
- TNF-ALPHA