Trans Fatty Acid-Induced NF-kappaB Activation Does Not Induce Insulin Resistance in Cultured Murine Skeletal Muscle Cells

P.P. Hommelberg, R.C.J. Langen*, A.M.W.J. Schols, A.L. van Essen, F.J. Snepvangers, R.P. Mensink, J. Plat

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Long-chain saturated fatty acids such as palmitic acid induce insulin resistance and NF-kappaB activation in skeletal muscle cells. Here we investigated the effects of long-chain fatty acid (FA) saturation and configuration on NF-kappaB activity and insulin sensitivity in cultured skeletal muscle cells. Of all tested unsaturated FAs, only elaidic acid (3-fold), cis9,trans11-CLA (3-fold) and trans10,cis12-CLA (13-fold) increased NF-kappaB transactivation in myotubes. This was not accompanied by decreased insulin sensitivity (measured as insulin-induced glucose uptake and GLUT4 translocation). We therefore conclude that FA-induced NF-kappaB activation is not sufficient for the induction of insulin resistance in skeletal muscle cells.
Original languageEnglish
Pages (from-to)285-290
Issue number3
Publication statusPublished - 1 Jan 2010

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