Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation

Norihiro Kato, Marie Loh, Fumihiko Takeuchi, Niek Verweij, Xu Wang, Weihua Zhang, Tanika N. Kelly, Danish Saleheen, Benjamin Lehne, Irene Mateo Leach, Alexander W. Drong, James Abbott, Simone Wahl, Sian-Tsung Tan, William R. Scott, Gianluca Campanella, Marc Chadeau-Hyam, Uzma Afzal, Tarunveer S. Ahluwalia, Marc Jan BonderPeng Chen, Abbas Dehghan, Todd L. Edwards, Tonu Esko, Min Jin Go, Sarah E. Harris, Jaana Hartiala, Silva Kasela, Anuradhani Kasturiratne, Chiea-Chuen Khor, Marcus E. Kleber, Huaixing Li, Zuan Yu Mok, Masahiro Nakatochi, Nur Sabrina Sapari, Richa Saxena, Alexandre F. R. Stewart, Lisette Stolk, Yasuharu Tabara, Ai Ling Teh, Ying Wu, Jer-Yuarn Wu, Yi Zhang, Imke Aits, Alexessander Da Silva Couto Alves, Shikta Das, Rajkumar Dorajoo, Jemma C. Hopewell, Yun Kyoung Kim, Robert W. Koivula, Jian'an Luan, Leo-Pekka Lyytikainen, Quang N. Nguyen, Mark A. Pereira, Iris Postmus, Olli T. Raitakari, Molly Scannell Bryan, Robert A. Scott, Rossella Sorice, Vinicius Tragante, Michela Traglia, Jon White, Ken Yamamoto, Yonghong Zhang, Linda S. Adair, Alauddin Ahmed, Koichi Akiyama, Rasheed Asif, Tin Aung, Ines Barroso, Andrew Bjonnes, Timothy R. Braun, Hui Cai, Li-Ching Chang, Chien-Hsiun Chen, Ching-Yu Cheng, Yap-Seng Chong, Rory Collins, Regina Courtney, Gail Davies, Graciela Delgado, Loi D. Do, Pieter A. Doevendans, Ron T. Gansevoort, Yu-Tang Gao, Tanja B. Grammer, Niels Grarup, Jagvir Grewal, Dongfeng Gu, Gurpreet S. Wander, Anna-Liisa Hartikainen, Stanley L. Hazen, Jing He, Chew-Kiat Heng, James E. Hixson, Albert Hofman, Chris Hsu, Wei Huang, Lise L. N. Husemoen, Joo-Yeon Hwang, Sahoko Ichihara, Michiya Igase, Masato Isono, Johanne M. Justesen, Tomohiro Katsuy, Muhammad G. Kibriya, Young Jin Kim, Miyako Kishimoto, Woon-Puay Koh, Katsuhiko Kohara, Meena Kumari, Kenneth Kwek, Nanette R. Lee, Jeannette Lee, Jiemin Liao, Wolfgang Lieb, David C. M. Liewald, Tatsuaki Matsubara, Yumi Matsushita, Thomas Meitinger, Evelin Mihailov, Lili Milani, Rebecca Mills, Nina Mononen, Martina Mueller-Nurasyid, Toru Nabika, Eitaro Nakashima, Hong Kiat Ng, Kjell Nikus, Teresa Nutile, Takayoshi Ohkubo, Keizo Ohnaka, Sarah Parish, Lavinia Paternoster, Hao Peng, Annette Peters, Son T. Pham, Mohitha J. Pinidiyapathirage, Mahfuzar Rahman, Hiromi Rakugi, Olov Rolandsson, Michelle Ann Rozario, Daniela Ruggiero, Cinzia F. Sala, Ralhan Sarju, Kazuro Shimokawa, Harold Snieder, Thomas Sparso, Wilko Spiering, John M. Starr, David J. Stott, Daniel O. Stram, Takao Sugiyama, Silke Szymczak, W. H. Wilson Tang, Lin Tong, Stella Trompet, Vaino Turjanmaa, Hirotsugu Ueshima, Andre G. Uitterlinden, Satoshi Umemura, Marja Vaarasmaki, Rob M. van Dam, Wiek H. van Gilst, Dirk J. van Veldhuisen, Jorma S. Viikari, Melanie Waldenberger, Yiqin Wang, Aili Wang, Rory Wilson, Tien-Yin Wong, Yong-Bing Xiang, Shuhei Yamaguchi, Xingwang Ye, Robin D. Young, Terri L. Young, Jian-Min Yuan, Xueya Zhou, Folkert W. Asselbergs, Marina Ciullo, Robert Clarke, Panos Deloukas, Andre Franke, Paul W. Franks, Steve Franks, Yechiel Friedlander, Myron D. Gross, Zhirong Guo, Torben Hansen, Marjo-Riitta Jarvelin, Torben Jorgensen, J. Wouter Jukema, Mika Kahonen, Hiroshi Kajio, Mika Kivimaki, Jong-Young Lee, Terho Lehtimaki, Allan Linneberg, Tetsuro Miki, Oluf Pedersen, Nilesh J. Samani, Thorkild I. A. Sorensen, Ryoichi Takayanagi, Daniela Toniolo, Habibul Ahsan, Hooman Allayee, Yuan-Tsong Chen, John Danesh, Ian J. Deary, Oscar H. Franco, Lude Franke, Bastiaan T. Heijman, Joanna D. Holbrook, Aaron Isaacs, Bong-Jo Kim, Xu Lin, Jianjun Liu, Winfried Maerz, Andres Metspalu, Karen L. Mohlke, Dharambir K. Sanghera, Xiao-Ou Shu, Joyce B. J. van Meurs, Eranga Vithana, Ananda R. Wickremasinghe, Cisca Wijmenga, Bruce H. W. Wolffenbuttel, Mitsuhiro Yokota, Wei Zheng, Dingliang Zhu, Paolo Vineis, Soterios A. Kyrtopoulos, Jos C. S. Kleinjans, Mark I. McCarthy, Richie Soong, Christian Gieger, James Scott, Yik-Ying Teo, Jiang He, Paul Elliott, E. Shyong Tai, Pim van der Harst, Jaspal S. Kooner, John C. Chambers

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38 Citations (Scopus)
Original languageEnglish
Pages (from-to)1282-+
JournalNature Genetics
Volume47
Issue number11
DOIs
Publication statusPublished - Nov 2015

Cite this

Kato, N., Loh, M., Takeuchi, F., Verweij, N., Wang, X., Zhang, W., Kelly, T. N., Saleheen, D., Lehne, B., Leach, I. M., Drong, A. W., Abbott, J., Wahl, S., Tan, S-T., Scott, W. R., Campanella, G., Chadeau-Hyam, M., Afzal, U., Ahluwalia, T. S., ... Chambers, J. C. (2015). Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation. Nature Genetics, 47(11), 1282-+. https://doi.org/10.1038/ng.3405