TraceLink: A model of consolidation and amnesia

M Meeter*, JMJ Murre

*Corresponding author for this work

    Research output: Contribution to journal(Systematic) Review article peer-review

    34 Citations (Web of Science)

    Abstract

    A connectionist model is presented, the TraceLink model, that implements an autonomous "off- line" consolidation process. The model consists of three subsystems: ( 1) a trace system ( neocortex), ( 2) a link system ( hippocampus and adjacent regions), and ( 3) a modulatory system ( basal forebrain and other areas). The model is able to account for many of the characteristics of anterograde and retrograde amnesia, including Ribot gradients, transient global amnesia, patterns of shrinkage of retrograde amnesia, and correlations between anterograde and retrograde amnesia or the absence thereof ( e. g., in isolated retrograde amnesia). In addition, it produces normal forgetting curves and can exhibit permastore. It also offers an explanation for the advantages of learning under high arousal for long-term retention.

    Original languageEnglish
    Pages (from-to)559-587
    Number of pages29
    JournalCognitive Neuropsychology
    Volume22
    Issue number5
    DOIs
    Publication statusPublished - Jul 2005

    Keywords

    • COMPLEMENTARY-LEARNING-SYSTEMS
    • ENDURING MEMORY IMPAIRMENT
    • TRANSIENT GLOBAL AMNESIA
    • LONG-TERM POTENTIATION
    • MEDIAL TEMPORAL-LOBE
    • RETROGRADE-AMNESIA
    • HIPPOCAMPAL-FORMATION
    • ALZHEIMERS-DISEASE
    • SEMANTIC MEMORY
    • AUTOBIOGRAPHICAL MEMORY

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