TY - JOUR
T1 - Towards the non-invasive determination of arterial wall distensible properties
T2 - New approach using old formulae
AU - Li, Ye
AU - Giudici, Alessandro
AU - Wilkinson, Ian B.
AU - Khir, Ashraf W.
N1 - Funding Information:
The authors would like to thank Addenbrook’s Hospital and Brunel University London for financial support to Alessandro Giudici.
Funding Information:
The authors would like to thank Addenbrook's Hospital and Brunel University London for financial support to Alessandro Giudici.
Publisher Copyright:
© 2020
PY - 2021/1/22
Y1 - 2021/1/22
N2 - Arterial function and wall mechanical properties are important determinants of hemodynamics in the circulation. However, their non-invasive determination is not widely available. Therefore, the aim of this work is to present a novel approach for the non-invasive determination of vessel's distensibility and elas-tic modulus.Simultaneous measurements of vessel's Diameter (D) and flow velocity (U) were recorded to determine local wave speed (C-n) in flexible tubes and calf aortas non-invasively using the lnDU-loop method, which was used to calculate the Distensibility (D-n(s)) and Elastic Modulus (E-n), also non-invasively. To validate the new approach, the non-invasive results were compared to traditionally invasive measurements of Dynamic Distensibility (D-sd) and Tangential Elastic Modulus (E-m).In flexible tubes, the average D-n(s) was higher and E-n was lower than Ds(d) and E-m by 1.6% and 6.9%, respectively. In calf aortas, the results of D-n(s) and E-n agreed well with those of D-sd and E-m, as demonstrated by Bland-Altman technique.The results of D-n(s) and nE are comparable to those determined using traditional techniques. Our results suggest that D-n(s) and E-n could be measured in-vivo non-invasively, given the possibility of measuring D and U to obtain C-n. Further studies are warranted to establish the clinical usefulness of the new approach. (C) 2020 Published by Elsevier Ltd.
AB - Arterial function and wall mechanical properties are important determinants of hemodynamics in the circulation. However, their non-invasive determination is not widely available. Therefore, the aim of this work is to present a novel approach for the non-invasive determination of vessel's distensibility and elas-tic modulus.Simultaneous measurements of vessel's Diameter (D) and flow velocity (U) were recorded to determine local wave speed (C-n) in flexible tubes and calf aortas non-invasively using the lnDU-loop method, which was used to calculate the Distensibility (D-n(s)) and Elastic Modulus (E-n), also non-invasively. To validate the new approach, the non-invasive results were compared to traditionally invasive measurements of Dynamic Distensibility (D-sd) and Tangential Elastic Modulus (E-m).In flexible tubes, the average D-n(s) was higher and E-n was lower than Ds(d) and E-m by 1.6% and 6.9%, respectively. In calf aortas, the results of D-n(s) and E-n agreed well with those of D-sd and E-m, as demonstrated by Bland-Altman technique.The results of D-n(s) and nE are comparable to those determined using traditional techniques. Our results suggest that D-n(s) and E-n could be measured in-vivo non-invasively, given the possibility of measuring D and U to obtain C-n. Further studies are warranted to establish the clinical usefulness of the new approach. (C) 2020 Published by Elsevier Ltd.
KW - Arterial function
KW - Distensibility
KW - Tangential elastic modulus
KW - Wave speed
KW - lnDU-loop
UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=researchintelligenceproject&SrcAuth=WosAPI&KeyUT=WOS:000701681500020&DestLinkType=FullRecord&DestApp=WOS
U2 - 10.1016/j.jbiomech.2020.110102
DO - 10.1016/j.jbiomech.2020.110102
M3 - Article
C2 - 33418244
SN - 0021-9290
VL - 115
JO - Journal of Biomechanics
JF - Journal of Biomechanics
ER -