Towards modeling anhedonia and its treatment in zebrafish

Murilo S de Abreu; Fabiano Costa; Ana C V V Giacomini; Konstantin A Demin; Konstantin N Zabegalov; Gleb O Maslov; Yuriy M Kositsyn; Elena V Petersen; Tatiana Strekalova; Denis B Rosemberg; Allan V Kalueff

doi:10.1093/ijnp/pyab092

Towards modeling anhedonia and its treatment in zebrafish

Murilo S de Abreu, Fabiano Costa, Ana C V V Giacomini, Konstantin A Demin, Konstantin N Zabegalov, Gleb O Maslov, Yuriy M Kositsyn, Elena V Petersen, Tatiana Strekalova, Denis B Rosemberg, Allan V Kalueff^*

^*Corresponding author for this work

Research output: Contribution to journal › (Systematic) Review article › peer-review

Abstract

Mood disorders, especially depression, are a major cause of human disability. The loss of pleasure (anhedonia) is a common, severely debilitating symptom of clinical depression. Experimental animal models are widely used to better understand depression pathogenesis and to develop novel antidepressant therapies. In rodents, various experimental models of anhedonia have already been developed and extensively validated. Complementing rodent studies, the zebrafish (Danio rerio) is emerging as a powerful model organism to assess pathobiological mechanisms of affective disorders, including depression. Here, we critically discuss the potential of zebrafish for modeling anhedonia and studying its molecular mechanisms and translational implications.

Original language	English
Pages (from-to)	293-306
Number of pages	14
Journal	International Journal of Neuropsychopharmacology
Volume	25
Issue number	4
Early online date	16 Dec 2021
DOIs	https://doi.org/10.1093/ijnp/pyab092
Publication status	Published - 19 Apr 2022

Keywords

ADULT ZEBRAFISH
ANIMAL-MODEL
Anhedonia
BIOLOGICAL MECHANISMS
CONDITIONED PLACE PREFERENCE
DANIO-RERIO
MAJOR DEPRESSIVE DISORDER
NUCLEUS-ACCUMBENS DOPAMINE
RECOGNITION MEMORY
SOCIAL-INTERACTION
STRESS-INDUCED ANHEDONIA
animal models
antidepressant
behavior
zebrafish

Access to Document

10.1093/ijnp/pyab092

Cite this

@article{935cf613fd974c629ec5b2095b9020d2,

title = "Towards modeling anhedonia and its treatment in zebrafish",

abstract = "Mood disorders, especially depression, are a major cause of human disability. The loss of pleasure (anhedonia) is a common, severely debilitating symptom of clinical depression. Experimental animal models are widely used to better understand depression pathogenesis and to develop novel antidepressant therapies. In rodents, various experimental models of anhedonia have already been developed and extensively validated. Complementing rodent studies, the zebrafish (Danio rerio) is emerging as a powerful model organism to assess pathobiological mechanisms of affective disorders, including depression. Here, we critically discuss the potential of zebrafish for modeling anhedonia and studying its molecular mechanisms and translational implications.",

keywords = "ADULT ZEBRAFISH, ANIMAL-MODEL, Anhedonia, BIOLOGICAL MECHANISMS, CONDITIONED PLACE PREFERENCE, DANIO-RERIO, MAJOR DEPRESSIVE DISORDER, NUCLEUS-ACCUMBENS DOPAMINE, RECOGNITION MEMORY, SOCIAL-INTERACTION, STRESS-INDUCED ANHEDONIA, animal models, antidepressant, behavior, zebrafish",

author = "{S de Abreu}, Murilo and Fabiano Costa and Giacomini, {Ana C V V} and Demin, {Konstantin A} and Zabegalov, {Konstantin N} and Maslov, {Gleb O} and Kositsyn, {Yuriy M} and Petersen, {Elena V} and Tatiana Strekalova and Rosemberg, {Denis B} and Kalueff, {Allan V}",

note = "{\textcopyright} The Author(s) 2021. Published by Oxford University Press on behalf of CINP.",

year = "2022",

month = apr,

day = "19",

doi = "10.1093/ijnp/pyab092",

language = "English",

volume = "25",

pages = "293--306",

journal = "International Journal of Neuropsychopharmacology",

issn = "1461-1457",

publisher = "Oxford University Press",

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TY - JOUR

T1 - Towards modeling anhedonia and its treatment in zebrafish

AU - S de Abreu, Murilo

AU - Costa, Fabiano

AU - Giacomini, Ana C V V

AU - Demin, Konstantin A

AU - Zabegalov, Konstantin N

AU - Maslov, Gleb O

AU - Kositsyn, Yuriy M

AU - Petersen, Elena V

AU - Strekalova, Tatiana

AU - Rosemberg, Denis B

AU - Kalueff, Allan V

N1 - © The Author(s) 2021. Published by Oxford University Press on behalf of CINP.

PY - 2022/4/19

Y1 - 2022/4/19

N2 - Mood disorders, especially depression, are a major cause of human disability. The loss of pleasure (anhedonia) is a common, severely debilitating symptom of clinical depression. Experimental animal models are widely used to better understand depression pathogenesis and to develop novel antidepressant therapies. In rodents, various experimental models of anhedonia have already been developed and extensively validated. Complementing rodent studies, the zebrafish (Danio rerio) is emerging as a powerful model organism to assess pathobiological mechanisms of affective disorders, including depression. Here, we critically discuss the potential of zebrafish for modeling anhedonia and studying its molecular mechanisms and translational implications.

AB - Mood disorders, especially depression, are a major cause of human disability. The loss of pleasure (anhedonia) is a common, severely debilitating symptom of clinical depression. Experimental animal models are widely used to better understand depression pathogenesis and to develop novel antidepressant therapies. In rodents, various experimental models of anhedonia have already been developed and extensively validated. Complementing rodent studies, the zebrafish (Danio rerio) is emerging as a powerful model organism to assess pathobiological mechanisms of affective disorders, including depression. Here, we critically discuss the potential of zebrafish for modeling anhedonia and studying its molecular mechanisms and translational implications.

KW - ADULT ZEBRAFISH

KW - ANIMAL-MODEL

KW - Anhedonia

KW - BIOLOGICAL MECHANISMS

KW - CONDITIONED PLACE PREFERENCE

KW - DANIO-RERIO

KW - MAJOR DEPRESSIVE DISORDER

KW - NUCLEUS-ACCUMBENS DOPAMINE

KW - RECOGNITION MEMORY

KW - SOCIAL-INTERACTION

KW - STRESS-INDUCED ANHEDONIA

KW - animal models

KW - antidepressant

KW - behavior

KW - zebrafish

U2 - 10.1093/ijnp/pyab092

DO - 10.1093/ijnp/pyab092

M3 - (Systematic) Review article

C2 - 34918075

SN - 1461-1457

VL - 25

SP - 293

EP - 306

JO - International Journal of Neuropsychopharmacology

JF - International Journal of Neuropsychopharmacology

IS - 4

ER -