Towards modeling anhedonia and its treatment in zebrafish

Murilo S de Abreu, Fabiano Costa, Ana C V V Giacomini, Konstantin A Demin, Konstantin N Zabegalov, Gleb O Maslov, Yuriy M Kositsyn, Elena V Petersen, Tatiana Strekalova, Denis B Rosemberg, Allan V Kalueff*

*Corresponding author for this work

Research output: Contribution to journal(Systematic) Review article peer-review

Abstract

Mood disorders, especially depression, are a major cause of human disability. The loss of pleasure (anhedonia) is a common, severely debilitating symptom of clinical depression. Experimental animal models are widely used to better understand depression pathogenesis and to develop novel antidepressant therapies. In rodents, various experimental models of anhedonia have already been developed and extensively validated. Complementing rodent studies, the zebrafish (Danio rerio) is emerging as a powerful model organism to assess pathobiological mechanisms of affective disorders, including depression. Here, we critically discuss the potential of zebrafish for modeling anhedonia and studying its molecular mechanisms and translational implications.

Original languageEnglish
Pages (from-to)293-306
Number of pages14
JournalInternational Journal of Neuropsychopharmacology
Volume25
Issue number4
Early online date16 Dec 2021
DOIs
Publication statusPublished - 19 Apr 2022

Keywords

  • ADULT ZEBRAFISH
  • ANIMAL-MODEL
  • Anhedonia
  • BIOLOGICAL MECHANISMS
  • CONDITIONED PLACE PREFERENCE
  • DANIO-RERIO
  • MAJOR DEPRESSIVE DISORDER
  • NUCLEUS-ACCUMBENS DOPAMINE
  • RECOGNITION MEMORY
  • SOCIAL-INTERACTION
  • STRESS-INDUCED ANHEDONIA
  • animal models
  • antidepressant
  • behavior
  • zebrafish

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