Abstract
Mood disorders, especially depression, are a major cause of human disability. The loss of pleasure (anhedonia) is a common, severely debilitating symptom of clinical depression. Experimental animal models are widely used to better understand depression pathogenesis and to develop novel antidepressant therapies. In rodents, various experimental models of anhedonia have already been developed and extensively validated. Complementing rodent studies, the zebrafish (Danio rerio) is emerging as a powerful model organism to assess pathobiological mechanisms of affective disorders, including depression. Here, we critically discuss the potential of zebrafish for modeling anhedonia and studying its molecular mechanisms and translational implications.
Original language | English |
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Pages (from-to) | 293-306 |
Number of pages | 14 |
Journal | International Journal of Neuropsychopharmacology |
Volume | 25 |
Issue number | 4 |
Early online date | 16 Dec 2021 |
DOIs | |
Publication status | Published - 19 Apr 2022 |
Keywords
- ADULT ZEBRAFISH
- ANIMAL-MODEL
- Anhedonia
- BIOLOGICAL MECHANISMS
- CONDITIONED PLACE PREFERENCE
- DANIO-RERIO
- MAJOR DEPRESSIVE DISORDER
- NUCLEUS-ACCUMBENS DOPAMINE
- RECOGNITION MEMORY
- SOCIAL-INTERACTION
- STRESS-INDUCED ANHEDONIA
- animal models
- antidepressant
- behavior
- zebrafish