Towards an improved definition of periprocedural myocardial infarction: The role of high-sensitivity cardiac troponins

S. Heuts*, I.C.C. van der Horst, A. Mingels

*Corresponding author for this work

Research output: Contribution to journalEditorialAcademicpeer-review


In the past few years, many have disputed the optimal biomarker for confirming or ruling out a diagnosis of periprocedural myocardial infarction (PMI) and the optimal cut-off concentrations to apply. In this issue of the Journal of Cardiac Surgery, Niclauss et al. performed a retrospective analysis of CK-MB and high-sensitivity cardiac troponin T (hs-cTnT) dynamics and peak concentrations following different cardiac surgical interventions in 400 patients during a 2-year period in a single center. The authors found that CK-MB and hs-cTnT predict PMI with a comparable diagnostic accuracy and discriminatory power >95%. They also attempted to propose an improved, more sensitive threshold of hs-cTnT for PMI. Their findings could have implications for clinical practice, but more research is warranted to identify more appropriate cut-offs. This could include hs-cTnT release pattern, slope steepness, and changes. Ultimately, this could results in patient-specific model, able to predict expected and abnormal ranges of hs-cTnT release, enabling an improved and timely diagnosis of PMI.
Original languageEnglish
Pages (from-to)162-164
Number of pages3
JournalJournal of Cardiac Surgery
Issue number1
Early online date24 Oct 2021
Publication statusPublished - Jan 2022


  • cardiac troponin
  • high-sensitivity cardiac troponin T
  • periprocedural myocardial infarction

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