Toward incorporating genetic risk scores into symptom networks of psychosis

Adela-Maria Isvoranu*, Sinan Guloksuz, Sacha Epskamp, Jim van Os, Denny Borsboom, Genetic Risk and Outcome of Psychosis (GROUP) Investigators

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

35 Citations (Web of Science)

Abstract

BACKGROUND: Psychosis spectrum disorder is a heterogeneous, multifactorial clinical phenotype, known to have a high heritability, only a minor portion of which can be explained by molecular measures of genetic variation. This study proposes that the identification of genetic variation underlying psychotic disorder may have suffered due to issues in the psychometric conceptualization of the phenotype. Here we aim to open a new line of research into the genetics of mental disorders by explicitly incorporating genes into symptom networks. Specifically, we investigate whether links between a polygenic risk score (PRS) for schizophrenia and measures of psychosis proneness can be identified in a network model.

METHODS: We analyzed data from n = 2180 subjects (controls, patients diagnosed with a non-affective psychotic disorder, and the first-degree relatives of the patients). A network structure was computed to examine associations between the 42 symptoms of the Community Assessment of Psychic Experiences (CAPE) and the PRS for schizophrenia.

RESULTS: The resulting network shows that the PRS is directly connected to the spectrum of positive and depressive symptoms, with the items conspiracy and no future being more often located on predictive pathways from PRS to other symptoms.

CONCLUSIONS: To our knowledge, the current exploratory study provides a first application of the network framework to the field of behavior genetics research. This allows for a novel outlook on the investigation of the relations between genome-wide association study-based PRSs and symptoms of mental disorders, by focusing on the dependencies among variables.

Original languageEnglish
Pages (from-to)636-643
Number of pages8
JournalPsychological Medicine
Volume50
Issue number4
DOIs
Publication statusPublished - Mar 2020

Keywords

  • GWAS
  • network analysis
  • polygenic risk score
  • psychosis
  • schizophrenia
  • POLYGENIC RISK
  • SCHIZOPHRENIA
  • CENTRALITY
  • DISORDER

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