Toward a science-based testing strategy to identify maternal thyroid hormone imbalance and neurodevelopmental effects in the progeny - part I: which parameters from human studies are most relevant for toxicological assessments?

Ursula G. Sauer, Alex Asiimwe, Philip A. Botham, Alex Charlton, Nina Hallmark, Sylvia Jacobi, Sue Marty, Stephanie Melching-Kollmuss, Joana A. Palha, Volker Strauss, Bennard van Ravenzwaay*, Gerard Swaen

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

Original languageEnglish
Pages (from-to)740-763
Number of pages24
JournalCritical Reviews in Toxicology
Issue number9
Early online date10 Dec 2020
Publication statusPublished - 11 Dec 2020


  • Free thyroxine (fT4)
  • thyroid stimulating hormone (TSH)
  • thyroid disruption
  • developmental neurotoxicity
  • uridine diphosphate glucuronyltransferase (UGT)
  • adverse outcome pathway (AOP)
  • brain development
  • pregnancy
  • European Union guidelines
  • endocrine disruptors

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