Total energy expenditure in stable patients with cystic fibrosis.

M. McCloskey*, A.O.B. Redmond, S. Pyper, C. McCabe, K.R. Westerterp, J.S. Elborn

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

89 Downloads (Pure)


Clin Nutr 2001 Jun;20(3):235-41 Related Articles, Books, LinkOut

Total energy expenditure in stable patients with cystic fibrosis.

McCloskey M, Redmond AO, Pyper S, McCabe C, Westerterp KR, Elborn JS.

Adult and Paediatric Cystic Fibrosis Centres Belfast City Hospital and Royal Belfast Hospital for Sick Children, Belfast, Northern Ireland.

BACKGROUND AND AIMS: Undernutrition is a common problem in patients with cystic fibrosis and is associated with a poor prognosis. The two aims of this study were to assess and compare the two main field techniques in the measurement of total energy expenditure and, secondly, to assess total energy expenditure in stable patients and compare with healthy controls. METHODS: Resting energy expenditure was measured using indirect calorimetry and total energy expenditure was measured using 24-h heart rate (HR) methodology and doubly isotopically labelled water. RESULTS: Seventeen patients, mean age 23 years and FEV(1)52% predicted and thirteen controls were recruited. Resting energy expenditure was higher in patients 0.24 (0.03) MJ/kg Fat-Free Mass (FFM) compared to controls 0.22 (0.02) MJ/kg FFM, P=0.02. Twenty-four hour heart rate underestimated total energy expenditure, 9.49 (1.85) MJ/day in patients compared to 11.69 (2.79) MJ/day using doubly labelled water. There was no difference in total energy expenditure in patients and controls using both methods, 11.69 (2.79) MJ/day compared to 11.38 (2.71) MJ/day using doubly isotopically labelled water. CONCLUSIONS: In clinically stable young adult patients with moderately severe respiratory disease total energy expenditure is comparable to that an a control population despite in increase in resting energy expenditure and both 24-h HR and doubly isotopically labelled water are suitable for use in patients with cystic fibrosis. Copyright 2001 Harcourt Publishers Ltd.

Original languageEnglish
Pages (from-to)235-241
Number of pages7
JournalClinical Nutrition
Publication statusPublished - 1 Jan 2001


Dive into the research topics of 'Total energy expenditure in stable patients with cystic fibrosis.'. Together they form a unique fingerprint.

Cite this