Tonic GABA(A) Receptors as Potential Target for the Treatment of Temporal Lobe Epilepsy

S. Schipper*, M. W. Aalbers, K. Rijkers, A. Swijsen, J. M. Rigo, G. Hoogland, J. S. H. Vles

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

26 Citations (Web of Science)

Abstract

Tonic GABA(A) receptors are a subpopulation of receptors that generate long-lasting inhibition and thereby control network excitability. In recent years, these receptors have been implicated in various neurological and psychiatric disorders, including Parkinson's disease, schizophrenia, and epilepsy. Their distinct subunit composition and function, compared to phasic GABA(A) receptors, opens the possibility to specifically modulate network properties. In this review, the role of tonic GABA(A) receptors in epilepsy and as potential antiepileptic target will be discussed.
Original languageEnglish
Pages (from-to)5252-5265
JournalMolecular Neurobiology
Volume53
Issue number8
DOIs
Publication statusPublished - Oct 2016

Keywords

  • Extrasynaptic GABA(A) receptor
  • Epilepsy
  • Seizures
  • Tonic
  • Antiepileptic drugs

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