Tonic and Phasic Changes in Anteromedial Globus Pallidus Activity in Tourette Syndrome

Michal Israelashvili; Anouk Y. J. M. Smeets; Maya Bronfeld; Dagmar H. Zeef; Albert F. G. Leentjens; Vivianne van Kranen-Mastenbroek; Marcus L. F. Janssen; Yasin Temel; Linda Ackermans; Izhar Bar-Gad

doi:10.1002/mds.27043

Tonic and Phasic Changes in Anteromedial Globus Pallidus Activity in Tourette Syndrome

Michal Israelashvili, Anouk Y. J. M. Smeets, Maya Bronfeld, Dagmar H. Zeef, Albert F. G. Leentjens, Vivianne van Kranen-Mastenbroek, Marcus L. F. Janssen, Yasin Temel, Linda Ackermans, Izhar Bar-Gad^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Background: Tourette syndrome is a hyperkinetic neurodevelopmental disorder characterized by tics.

Objective: Assess the neuronal changes in the associative/limbic GP associated with Tourette syndrome.

Methods: Neurophysiological recordings were performed from the anterior (associative/limbic) GPe and GPi of 8 awake patients during DBS electrode implantation surgeries.

Results: The baseline firing rate of the neurons was low in a state-dependent manner in both segments of the GP. Tic-dependent transient rate changes were found in the activity of individual neurons of both segments around the time of the tic. Neither oscillatory activity of individual neurons nor correlations in their interactions were observed.

Conclusions: The results demonstrate the involvement of the associative/limbic pathway in the underlying pathophysiology of Tourette syndrome and point to tonic and phasic modulations of basal ganglia output as a key mechanisms underlying the abnormal state of the disorder and the expression of individual tics, respectively. (C) 2017 International Parkinson and Movement Disorder Society

Original language	English
Pages (from-to)	1091-1096
Number of pages	6
Journal	Movement Disorders
Volume	32
Issue number	7
DOIs	https://doi.org/10.1002/mds.27043
Publication status	Published - Jul 2017

Keywords

Tourette syndrome
deep brain stimulation (DBS)
globus pallidus
neurophysiology
hyperkinetic disorders
DEEP BRAIN-STIMULATION
BASAL GANGLIA
NEURONAL-ACTIVITY
PARKINSONS-DISEASE
MOTOR TICS
DYSTONIA
DISCHARGE
OSCILLATIONS
INDIVIDUALS
PARVALBUMIN

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10.1002/mds.27043

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Cite this

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title = "Tonic and Phasic Changes in Anteromedial Globus Pallidus Activity in Tourette Syndrome",

abstract = "Background: Tourette syndrome is a hyperkinetic neurodevelopmental disorder characterized by tics.Objective: Assess the neuronal changes in the associative/limbic GP associated with Tourette syndrome.Methods: Neurophysiological recordings were performed from the anterior (associative/limbic) GPe and GPi of 8 awake patients during DBS electrode implantation surgeries.Results: The baseline firing rate of the neurons was low in a state-dependent manner in both segments of the GP. Tic-dependent transient rate changes were found in the activity of individual neurons of both segments around the time of the tic. Neither oscillatory activity of individual neurons nor correlations in their interactions were observed.Conclusions: The results demonstrate the involvement of the associative/limbic pathway in the underlying pathophysiology of Tourette syndrome and point to tonic and phasic modulations of basal ganglia output as a key mechanisms underlying the abnormal state of the disorder and the expression of individual tics, respectively. (C) 2017 International Parkinson and Movement Disorder Society",

keywords = "Tourette syndrome, deep brain stimulation (DBS), globus pallidus, neurophysiology, hyperkinetic disorders, DEEP BRAIN-STIMULATION, BASAL GANGLIA, NEURONAL-ACTIVITY, PARKINSONS-DISEASE, MOTOR TICS, DYSTONIA, DISCHARGE, OSCILLATIONS, INDIVIDUALS, PARVALBUMIN",

author = "Michal Israelashvili and Smeets, {Anouk Y. J. M.} and Maya Bronfeld and Zeef, {Dagmar H.} and Leentjens, {Albert F. G.} and {van Kranen-Mastenbroek}, Vivianne and Janssen, {Marcus L. F.} and Yasin Temel and Linda Ackermans and Izhar Bar-Gad",

year = "2017",

month = jul,

doi = "10.1002/mds.27043",

language = "English",

volume = "32",

pages = "1091--1096",

journal = "Movement Disorders",

issn = "0885-3185",

publisher = "Wiley",

number = "7",

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T1 - Tonic and Phasic Changes in Anteromedial Globus Pallidus Activity in Tourette Syndrome

AU - Israelashvili, Michal

AU - Smeets, Anouk Y. J. M.

AU - Bronfeld, Maya

AU - Zeef, Dagmar H.

AU - Leentjens, Albert F. G.

AU - van Kranen-Mastenbroek, Vivianne

AU - Janssen, Marcus L. F.

AU - Temel, Yasin

AU - Ackermans, Linda

AU - Bar-Gad, Izhar

PY - 2017/7

Y1 - 2017/7

N2 - Background: Tourette syndrome is a hyperkinetic neurodevelopmental disorder characterized by tics.Objective: Assess the neuronal changes in the associative/limbic GP associated with Tourette syndrome.Methods: Neurophysiological recordings were performed from the anterior (associative/limbic) GPe and GPi of 8 awake patients during DBS electrode implantation surgeries.Results: The baseline firing rate of the neurons was low in a state-dependent manner in both segments of the GP. Tic-dependent transient rate changes were found in the activity of individual neurons of both segments around the time of the tic. Neither oscillatory activity of individual neurons nor correlations in their interactions were observed.Conclusions: The results demonstrate the involvement of the associative/limbic pathway in the underlying pathophysiology of Tourette syndrome and point to tonic and phasic modulations of basal ganglia output as a key mechanisms underlying the abnormal state of the disorder and the expression of individual tics, respectively. (C) 2017 International Parkinson and Movement Disorder Society

AB - Background: Tourette syndrome is a hyperkinetic neurodevelopmental disorder characterized by tics.Objective: Assess the neuronal changes in the associative/limbic GP associated with Tourette syndrome.Methods: Neurophysiological recordings were performed from the anterior (associative/limbic) GPe and GPi of 8 awake patients during DBS electrode implantation surgeries.Results: The baseline firing rate of the neurons was low in a state-dependent manner in both segments of the GP. Tic-dependent transient rate changes were found in the activity of individual neurons of both segments around the time of the tic. Neither oscillatory activity of individual neurons nor correlations in their interactions were observed.Conclusions: The results demonstrate the involvement of the associative/limbic pathway in the underlying pathophysiology of Tourette syndrome and point to tonic and phasic modulations of basal ganglia output as a key mechanisms underlying the abnormal state of the disorder and the expression of individual tics, respectively. (C) 2017 International Parkinson and Movement Disorder Society

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