Toll-like receptor 4 polymorphism associated with the response to whole-cell pertussis vaccination in children from the KOALA study.

S. Banus, R.W. Bottema, C.L. Siezen, R.J. Vandebriel, J. Reimerink, M. Mommers, G.H. Koppelman, B. Hoebee, C. Thijs, D.S. Postma, T.G. Kimman*, F.F. Stelma

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


We examined the association between haplotype tagging single-nucleotide polymorphisms in TLR4 and the pertussis toxin-specific immunoglobulin G response after whole-cell pertussis (wP) vaccination in 515 1-year-old children from the KOALA study. A lower titer was associated with the minor allele of rs2770150, supporting a role for Toll-like receptor 4 in the antibody response to wP vaccination.

Original languageEnglish
Pages (from-to)1377-1380
JournalClinical and Vaccine Immunology
Issue number10
Publication statusPublished - 1 Jan 2007

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