Toll-like receptor 4 polymorphism associated with the response to whole-cell pertussis vaccination in children from the KOALA study.

S. Banus; R.W. Bottema; C.L. Siezen; R.J. Vandebriel; J. Reimerink; M. Mommers; G.H. Koppelman; B. Hoebee; C. Thijs; D.S. Postma; T.G. Kimman; F.F. Stelma

doi:10.1128/CVI.00175-07

Toll-like receptor 4 polymorphism associated with the response to whole-cell pertussis vaccination in children from the KOALA study.

S. Banus, R.W. Bottema, C.L. Siezen, R.J. Vandebriel, J. Reimerink, M. Mommers, G.H. Koppelman, B. Hoebee, C. Thijs, D.S. Postma, T.G. Kimman^*, F.F. Stelma

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

We examined the association between haplotype tagging single-nucleotide polymorphisms in TLR4 and the pertussis toxin-specific immunoglobulin G response after whole-cell pertussis (wP) vaccination in 515 1-year-old children from the KOALA study. A lower titer was associated with the minor allele of rs2770150, supporting a role for Toll-like receptor 4 in the antibody response to wP vaccination.

Original language	English
Pages (from-to)	1377-1380
Journal	Clinical and Vaccine Immunology
Volume	14
Issue number	10
DOIs	https://doi.org/10.1128/CVI.00175-07
Publication status	Published - 1 Jan 2007

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10.1128/CVI.00175-07

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Banus, S., Bottema, R. W., Siezen, C. L., Vandebriel, R. J., Reimerink, J., Mommers, M., Koppelman, G. H., Hoebee, B., Thijs, C., Postma, D. S., Kimman, T. G., & Stelma, F. F. (2007). Toll-like receptor 4 polymorphism associated with the response to whole-cell pertussis vaccination in children from the KOALA study. Clinical and Vaccine Immunology, 14(10), 1377-1380. https://doi.org/10.1128/CVI.00175-07

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abstract = "We examined the association between haplotype tagging single-nucleotide polymorphisms in TLR4 and the pertussis toxin-specific immunoglobulin G response after whole-cell pertussis (wP) vaccination in 515 1-year-old children from the KOALA study. A lower titer was associated with the minor allele of rs2770150, supporting a role for Toll-like receptor 4 in the antibody response to wP vaccination.",

author = "S. Banus and R.W. Bottema and C.L. Siezen and R.J. Vandebriel and J. Reimerink and M. Mommers and G.H. Koppelman and B. Hoebee and C. Thijs and D.S. Postma and T.G. Kimman and F.F. Stelma",

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Banus, S, Bottema, RW, Siezen, CL, Vandebriel, RJ, Reimerink, J, Mommers, M, Koppelman, GH, Hoebee, B, Thijs, C, Postma, DS, Kimman, TG & Stelma, FF 2007, 'Toll-like receptor 4 polymorphism associated with the response to whole-cell pertussis vaccination in children from the KOALA study.', Clinical and Vaccine Immunology, vol. 14, no. 10, pp. 1377-1380. https://doi.org/10.1128/CVI.00175-07

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AU - Bottema, R.W.

AU - Siezen, C.L.

AU - Vandebriel, R.J.

AU - Reimerink, J.

AU - Mommers, M.

AU - Koppelman, G.H.

AU - Hoebee, B.

AU - Thijs, C.

AU - Postma, D.S.

AU - Kimman, T.G.

AU - Stelma, F.F.

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AB - We examined the association between haplotype tagging single-nucleotide polymorphisms in TLR4 and the pertussis toxin-specific immunoglobulin G response after whole-cell pertussis (wP) vaccination in 515 1-year-old children from the KOALA study. A lower titer was associated with the minor allele of rs2770150, supporting a role for Toll-like receptor 4 in the antibody response to wP vaccination.

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