We examined the association between haplotype tagging single-nucleotide polymorphisms in TLR4 and the pertussis toxin-specific immunoglobulin G response after whole-cell pertussis (wP) vaccination in 515 1-year-old children from the KOALA study. A lower titer was associated with the minor allele of rs2770150, supporting a role for Toll-like receptor 4 in the antibody response to wP vaccination.
Banus, S., Bottema, R. W., Siezen, C. L., Vandebriel, R. J., Reimerink, J., Mommers, M., Koppelman, G. H., Hoebee, B., Thijs, C., Postma, D. S., Kimman, T. G., & Stelma, F. F. (2007). Toll-like receptor 4 polymorphism associated with the response to whole-cell pertussis vaccination in children from the KOALA study. Clinical and Vaccine Immunology, 14(10), 1377-1380. https://doi.org/10.1128/CVI.00175-07