Toenail selenium status and the risk of Barrett's esophagus: the Netherlands Cohort Study

J. Steevens, L.J. Schouten, A.L.C. Driessen, C.J. Huysentruyt, Y.C. Keulemans, R.A. Goldbohm, P.A. van den Brandt

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

OBJECTIVE: To investigate the association between selenium and the risk of Barrett's esophagus (BE), the precursor lesion of esophageal adenocarcinoma. METHODS: Data from the prospective Netherlands Cohort Study were used. This cohort study was initiated in 1986, when 120,852 subjects aged 55-69 years completed a questionnaire on dietary habits and lifestyle, and provided toenail clippings for the determination of baseline selenium status. After 16.3 years of follow-up, 253 BE cases (identified through linkage with the nationwide Dutch pathology registry) and 2,039 subcohort members were available for case-cohort analysis. Cox proportional hazards models were used to calculate incidence rate ratios (RR). RESULTS: The multivariable-adjusted RR for the highest versus the lowest quartile of toenail selenium was 1.06 (95% CI 0.71-1.57). No dose-response trend was seen (p trend = 0.99). No association was found in subgroups defined by sex, smoking status, body mass index (BMI), or intake of antioxidants. For BE cases that later progressed to high-grade dysplasia or adenocarcinoma, the RR for a selenium level above the median vs. below the median was 0.64 (95% CI 0.24-1.76). CONCLUSIONS: In this large prospective cohort study, we found no evidence of an association between selenium and risk of BE.
Original languageEnglish
Pages (from-to)2259-2268
Number of pages10
JournalCancer Causes & Control
Volume21
Issue number12
DOIs
Publication statusPublished - Dec 2010

Keywords

  • Barrett esophagus
  • Biological markers
  • Selenium
  • SCALE PROSPECTIVE COHORT
  • HIGH-GRADE DYSPLASIA
  • CANCER PREVENTION
  • SERUM SELENIUM
  • ADENOCARCINOMA
  • DIETARY
  • MEN
  • DNA
  • METAANALYSIS
  • PREVALENCE

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