Abstract
OBJECTIVE: To investigate the association between selenium and the risk of Barrett's esophagus (BE), the precursor lesion of esophageal adenocarcinoma. METHODS: Data from the prospective Netherlands Cohort Study were used. This cohort study was initiated in 1986, when 120,852 subjects aged 55-69 years completed a questionnaire on dietary habits and lifestyle, and provided toenail clippings for the determination of baseline selenium status. After 16.3 years of follow-up, 253 BE cases (identified through linkage with the nationwide Dutch pathology registry) and 2,039 subcohort members were available for case-cohort analysis. Cox proportional hazards models were used to calculate incidence rate ratios (RR). RESULTS: The multivariable-adjusted RR for the highest versus the lowest quartile of toenail selenium was 1.06 (95% CI 0.71-1.57). No dose-response trend was seen (p trend = 0.99). No association was found in subgroups defined by sex, smoking status, body mass index (BMI), or intake of antioxidants. For BE cases that later progressed to high-grade dysplasia or adenocarcinoma, the RR for a selenium level above the median vs. below the median was 0.64 (95% CI 0.24-1.76). CONCLUSIONS: In this large prospective cohort study, we found no evidence of an association between selenium and risk of BE.
Original language | English |
---|---|
Pages (from-to) | 2259-2268 |
Number of pages | 10 |
Journal | Cancer Causes & Control |
Volume | 21 |
Issue number | 12 |
DOIs | |
Publication status | Published - Dec 2010 |
Keywords
- Barrett esophagus
- Biological markers
- Selenium
- SCALE PROSPECTIVE COHORT
- HIGH-GRADE DYSPLASIA
- CANCER PREVENTION
- SERUM SELENIUM
- ADENOCARCINOMA
- DIETARY
- MEN
- DNA
- METAANALYSIS
- PREVALENCE