TMTHSI, a superior 7-membered ring alkyne containing reagent for strain-promoted azide-alkyne cycloaddition reactions

Jimmy Weterings, Cristianne J. F. Rijcken, Harald Veldhuis, Tommi Meulemans, Darya Hadavi, Matt Timmers, Maarten Honing, Hans Ippel, Rob M. J. Liskamp*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Web of Science)

Abstract

We describe the development of TMTH-SulfoxImine (TMTHSI) as a superior click reagent. This reagent combines a great reactivity, with small size and low hydrophobicity and compares outstandingly with existing click reagents. TMTHSI can be conveniently functionalized with a variety of linkers allowing attachment of a diversity of small molecules and (peptide, nucleic acid) biologics.

Original languageEnglish
Pages (from-to)9011-9016
Number of pages6
JournalChemical Science
Volume11
Issue number33
DOIs
Publication statusPublished - 7 Sep 2020

Keywords

  • CLICK CHEMISTRY
  • SULFOXIMINES

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