Timed Get Up and Go Test and Geriatric 8 Scores and the Association With (Chemo-) Radiation Therapy Noncompliance and Acute Toxicity in Elderly Cancer Patients

Judith G. Middelburg*, Mirjam E. Mast, Maaike de Kroon, Jan J. Jobsen, Tom Rozema, Huub Maas, Elizabet A. Baartman, Debby Geijsen, Annija H. van der Leest, Desiree J. van den Bongard, Judith van Loon, Tom Budiharto, Jan Willem Coebergh, Mieke J. Aarts, Henk Struikmans, LPRO Dutch Natl Org Radiotherap

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

25 Citations (Web of Science)


Purpose: To investigate whether the Geriatric 8 (G8) and the Timed Get Up and Go Test (TGUGT) and clinical and demographic patient characteristics were associated with acute toxicity of radiation therapy and noncompliance in elderly cancer patients being irradiated with curative intent.

Methods and Materials: Patients were eligible if aged >= 65 years and diagnosed with breast, non-small cell lung, prostate, head and neck, rectal, or esophageal cancer, and were referred for curative radiation therapy. We recorded acute toxicity and noncompliance and identified potential predictors, including the G8 and TGUGT.

Results: We investigated 402 patients with a median age of 72 years (range, 65-96 years). According to the G8, 44.4% of the patients were frail. Toxicity grade >= 3 was observed in 22% of patients who were frail according to the G8 and 9.1% of patients who were not frail. The difference was 13% (confidence interval 5.2%-20%; P=.0006). According to the TGUGT 18.8% of the patients were frail; 21% of the frail according to the TGUGT developed toxicity grade > 3, compared with 13% who were not frail. The difference was 7.3% (confidence interval -2.7% to 17%; P=.11). Overall compliance was 95%. Toxicity was most strongly associated with type of primary tumor, chemotherapy, age, and World Health Organization performance status. Compliance was associated with type of primary tumor and age.

Conclusions: The usefulness of the TGUGT and G8 score in daily practice seems to be limited. Type of primary tumor, chemoradiotherapy, age, and World Health Organization performance status were more strongly associated with acute toxicity. Only chemoradiotherapy and age were associated with noncompliance. Overall the compliance was very high. To allow better-informed treatment decisions, a more accurate prediction of toxicity is desirable. (C) 2017 Published by Elsevier Inc.

Original languageEnglish
Pages (from-to)843-849
Number of pages7
JournalInternational Journal of Radiation Oncology Biology Physics
Issue number4
Publication statusPublished - 15 Jul 2017


  • HEAD

Cite this