Time spent at blood pressure target and the risk of death and cardiovascular diseases

Sheng-Chia Chung*, Mar Pujades-Rodriguez, Bram Duyx, Spiros C. Denaxas, Laura Pasea, Aroon Hingorani, Adam Timmis, Bryan Williams, Harry Hemingway

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Web of Science)

Abstract

Background The time a patient spends with blood pressure at target level is an intuitive measure of successful BP management, but population studies on its effectiveness are as yet unavailable. Method We identified a population-based cohort of 169,082 individuals with newly identified high blood pressure who were free of cardiovascular disease from January 1997 to March 2010. We used 1.64 million clinical blood pressure readings to calculate the TIme at TaRgEt (TITRE) based on current target blood pressure levels. Result The median (Inter-quartile range) TITRE among all patients was 2.8 (0.3, 5.6) months per year, only 1077 (0.6%) patients had a TITRE >= 11 months. Compared to people with a 0% TITRE, patients with a TITRE of 3-5.9 months, and 6-8.9 months had 75% and 78% lower odds of the composite of cardiovascular death, myocardial infarction and stroke (adjusted odds ratios, 0.25 (95% confidence interval: 0.21, 0.31) and 0.22 (0.17, 0.27), respectively). These associations were consistent for heart failure and any cardiovascular disease and death (comparing a 3-5.9 month to 0% TITRE, 63% and 60% lower in odds, respectively), among people who did or did not have blood pressure 'controlled' on a single occasion during the first year of follow-up, and across groups defined by number of follow-up BP measure categories. Conclusion Based on the current frequency of measurement of blood pressure this study suggests that few newly hypertensive patients sustained a complete, year-round on target blood pressure over time. The inverse associations between a higher TITRE and lower risk of incident cardiovascular diseases were independent of widely-used blood pressure 'control' indicators. Randomized trials are required to evaluate interventions to increase a person's time spent at blood pressure target.
Original languageEnglish
Article numbere0202359
Pages (from-to)e0202359
Number of pages18
JournalPLOS ONE
Volume13
Issue number9
DOIs
Publication statusPublished - 5 Sep 2018

Keywords

  • RANDOMIZED-TRIAL
  • MILLION PEOPLE
  • EPISODIC HYPERTENSION
  • PRIMARY-CARE
  • PREVALENCE
  • MANAGEMENT
  • COHORT
  • METAANALYSIS
  • VARIABILITY
  • GUIDELINES
  • AWARENESS
  • HYPERTENSION
  • AGE
  • Cardiovascular Diseases/mortality
  • Humans
  • Middle Aged
  • Male
  • Time Factors
  • Adult
  • Female
  • Blood Pressure Determination
  • Hypertension/drug therapy
  • Antihypertensive Agents/therapeutic use
  • Risk Factors
  • Survival Rate
  • Blood Pressure/drug effects
  • Aged
  • Cohort Studies

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