Time course gene expression data in colon of mice after exposure to food-grade E171

Héloïse Proquin; Marlon J Jetten; Marloes C M Jonkhout; Luis G Garduño-Balderas; Jacob J Briedé; Theo M de Kok; Yolanda I Chirino; Henk van Loveren

doi:10.1016/j.dib.2017.11.067

Time course gene expression data in colon of mice after exposure to food-grade E171

Héloïse Proquin^*, Marlon J Jetten, Marloes C M Jonkhout, Luis G Garduño-Balderas, Jacob J Briedé, Theo M de Kok, Yolanda I Chirino, Henk van Loveren

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

We investigated gene expression responses in BALB/c mice exposed by gavage to 5 mg/kg bw/day of E171 for 2, 7, 14 and 21 days. Food additive E171 (titanium dioxide) has been shown to induce oxidative stress and DNA damage in vitro as well as facilitating growth of colorectal tumours in vivo. Full genome expression changes of the colon of mice were investigated by using Agilent SurePrint G3 mouse Gene exp 60kv2 microarrays slides. The data presented in this DiB include all differentially expressed for each time point with EntrezGeneID, gene symbols, gene names and Log2FC as well as genes included in pathways after over-representation analysis in ConsensusPathDataBase. The functions of these genes in relation to the colon were described in our associated article (Proquin et al., 2017 in press) [1]. Raw and normalized gene expression data are available through NCBI GEO (GEO accession: GSE92563).

Original language	English
Pages (from-to)	531-600
Number of pages	70
Journal	Data in brief
Volume	16
DOIs	https://doi.org/10.1016/j.dib.2017.11.067
Publication status	Published - Feb 2018

Keywords

TITANIUM-DIOXIDE NANOPARTICLES
CONSENSUSPATHDB
PRODUCTS

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10.1016/j.dib.2017.11.067Licence: CC BY

Cite this

@article{f545e661c9654e1da494e4dd211d7586,

title = "Time course gene expression data in colon of mice after exposure to food-grade E171",

abstract = "We investigated gene expression responses in BALB/c mice exposed by gavage to 5 mg/kg bw/day of E171 for 2, 7, 14 and 21 days. Food additive E171 (titanium dioxide) has been shown to induce oxidative stress and DNA damage in vitro as well as facilitating growth of colorectal tumours in vivo. Full genome expression changes of the colon of mice were investigated by using Agilent SurePrint G3 mouse Gene exp 60kv2 microarrays slides. The data presented in this DiB include all differentially expressed for each time point with EntrezGeneID, gene symbols, gene names and Log2FC as well as genes included in pathways after over-representation analysis in ConsensusPathDataBase. The functions of these genes in relation to the colon were described in our associated article (Proquin et al., 2017 in press) [1]. Raw and normalized gene expression data are available through NCBI GEO (GEO accession: GSE92563).",

keywords = "TITANIUM-DIOXIDE NANOPARTICLES, CONSENSUSPATHDB, PRODUCTS",

author = "H{\'e}lo{\"i}se Proquin and Jetten, {Marlon J} and Jonkhout, {Marloes C M} and Gardu{\~n}o-Balderas, {Luis G} and Bried{\'e}, {Jacob J} and {de Kok}, {Theo M} and Chirino, {Yolanda I} and {van Loveren}, Henk",

year = "2018",

month = feb,

doi = "10.1016/j.dib.2017.11.067",

language = "English",

volume = "16",

pages = "531--600",

journal = "Data in brief",

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T1 - Time course gene expression data in colon of mice after exposure to food-grade E171

AU - Proquin, Héloïse

AU - Jetten, Marlon J

AU - Jonkhout, Marloes C M

AU - Garduño-Balderas, Luis G

AU - Briedé, Jacob J

AU - de Kok, Theo M

AU - Chirino, Yolanda I

AU - van Loveren, Henk

PY - 2018/2

Y1 - 2018/2

N2 - We investigated gene expression responses in BALB/c mice exposed by gavage to 5 mg/kg bw/day of E171 for 2, 7, 14 and 21 days. Food additive E171 (titanium dioxide) has been shown to induce oxidative stress and DNA damage in vitro as well as facilitating growth of colorectal tumours in vivo. Full genome expression changes of the colon of mice were investigated by using Agilent SurePrint G3 mouse Gene exp 60kv2 microarrays slides. The data presented in this DiB include all differentially expressed for each time point with EntrezGeneID, gene symbols, gene names and Log2FC as well as genes included in pathways after over-representation analysis in ConsensusPathDataBase. The functions of these genes in relation to the colon were described in our associated article (Proquin et al., 2017 in press) [1]. Raw and normalized gene expression data are available through NCBI GEO (GEO accession: GSE92563).

AB - We investigated gene expression responses in BALB/c mice exposed by gavage to 5 mg/kg bw/day of E171 for 2, 7, 14 and 21 days. Food additive E171 (titanium dioxide) has been shown to induce oxidative stress and DNA damage in vitro as well as facilitating growth of colorectal tumours in vivo. Full genome expression changes of the colon of mice were investigated by using Agilent SurePrint G3 mouse Gene exp 60kv2 microarrays slides. The data presented in this DiB include all differentially expressed for each time point with EntrezGeneID, gene symbols, gene names and Log2FC as well as genes included in pathways after over-representation analysis in ConsensusPathDataBase. The functions of these genes in relation to the colon were described in our associated article (Proquin et al., 2017 in press) [1]. Raw and normalized gene expression data are available through NCBI GEO (GEO accession: GSE92563).

KW - TITANIUM-DIOXIDE NANOPARTICLES

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KW - PRODUCTS

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SN - 2352-3409

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JO - Data in brief

JF - Data in brief

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