Abstract
In this issue of Blood, Van Laer et al have expressed and extensively characterized 8 thrombomodulin (TM) variants of uncertain significance identified in patients with venous thromboembolism (VTE) or bleeding, demonstrating defective anticoagulant activity in 2 of them (L433P and C175S).1 Their findings, reported in this issue of Blood, support a contributory role of these variants in the pathogenesis of VTE, strengthening the link between TM defects and VTE risk.
| Original language | English |
|---|---|
| Pages (from-to) | 1837-1839 |
| Number of pages | 3 |
| Journal | Blood |
| Volume | 145 |
| Issue number | 17 |
| DOIs | |
| Publication status | Published - 24 Apr 2025 |
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