Thrombin dynamics

Research output: ThesisDoctoral ThesisInternal


Cardiovascular diseases (CVDs) are the number one cause of death globally. In 2012, 17.5 million people died of CVDs, of which 43% were caused by ischemic heart disease and 38% by stroke.
Thrombosis plays a pivotal role in the development of ischemic heart disease and stroke. Therefore, the haemostatic system has been one of the main targets of prevent and clinical management of thrombosis related pathologies. Adequate diagnosis of a medical condition is pivotal in the fight against thrombosis and the development of a suitable diagnostic test that can accurately predict the thrombotic risk is essential in the development of an effective treatment strategy to treat thrombosis. In this thesis the thrombin dynamics method was introduced, a technique to investigate both the pro- and anticoagulant processes that underlie thrombin generation separately. This method was used to study how these two processes deviates in different patient groups such as patients with liver cirrhosis and patients who are being treated with anticoagulants.
Original languageEnglish
Awarding Institution
  • Maastricht University
  • ten Cate, Hugo, Supervisor
  • Hemker, Hendric, Supervisor
  • Wagenvoord, Robert, Co-Supervisor
  • de Laat, Bas, Co-Supervisor
Award date20 May 2016
Publication statusPublished - 2016


  • cardiovascular diseases
  • coagulation
  • diagnosis

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