Thioredoxin reductase 1 and NADPH directly protect protein tyrosine phosphatase 1B from inactivation during H2O2 exposure

Markus Dagnell, Paul E. Pace, Qing Cheng, Jeroen Frijhoff, Arne Ostman, Elias S. J. Arner, Mark B. Hampton, Christine C. Winterbourn*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Pages (from-to)14371-14380
Number of pages10
JournalJournal of Biological Chemistry
Volume292
Issue number35
DOIs
Publication statusPublished - 1 Sep 2017

Keywords

  • GROWTH-FACTOR
  • HYDROGEN-PEROXIDE
  • REACTIVE OXYGEN
  • REVERSIBLE INACTIVATION
  • SIGNAL-TRANSDUCTION
  • OXIDATIVE STRESS
  • REDOX REGULATION
  • OXIDIZED PTP1B
  • PEROXIREDOXIN
  • SYSTEM

Cite this

Dagnell, M., Pace, P. E., Cheng, Q., Frijhoff, J., Ostman, A., Arner, E. S. J., Hampton, M. B., & Winterbourn, C. C. (2017). Thioredoxin reductase 1 and NADPH directly protect protein tyrosine phosphatase 1B from inactivation during H2O2 exposure. Journal of Biological Chemistry, 292(35), 14371-14380. https://doi.org/10.1074/jbc.M117.793745