Thigh-length versus below-knee compression elastic stockings for prevention of the postthrombotic syndrome in patients with proximal-venous thrombosis: a randomized trial

Paolo Prandoni*, Franco Noventa, Roberto Quintavalla, Carlo Bova, Benilde Cosmi, Sergio Siragusa, Eugenio Bucherini, Francesco Astorri, Stefano Cuppini, Fabio Dalla Valle, Anthonie W. A. Lensing, Martin H. Prins, Sabina Villalta

*Corresponding author for this work

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Abstract

Although below-knee compression elastic stockings (CES) are effective for the prevention of the postthrombotic syndrome (PTS), a substantial number of patients with deep venous thrombosis still develop PTS. In the present openlabel, randomized clinical trial, we compared thigh-length with below-knee CES for the prevention of PTS. A total of 267 patients with the first episode of proximal deep venous thrombosis were randomized to wear either thigh-length or below-knee CES for 2 years. After 3, 6, 12, 18, 24, and 36 months, they were assessed for PTS manifestations according to the Villalta scale. PTS developed in 44 (32.6%) of the 135 patients randomized to thigh-length CES and in 47 (35.6%) of the 132 allocated to below-knee CES, for an adjusted hazard ratio of 0.93 (95% confidence interval, 0.62-1.41). Severe PTS developed in 3 patients in each group. CES-related side effects developed in 55 (40.7%) of the 135 patients allocated to thigh-length CES and in 36 (27.3%) of those randomized to the below-knee group (P = .017), and led to premature discontinuation of their use in 29 (21.5%) and 18 (13.6%) patients, respectively. We conclude that thigh-length CES do not offer a better protection against PTS than below-knee CES and are less well tolerated. This study is registered as Clinical Trial number NCT00426075. (Blood. 2012;119(6):1561-1565)
Original languageEnglish
Pages (from-to)1561-1565
JournalBlood
Volume119
Issue number6
DOIs
Publication statusPublished - 9 Feb 2012

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