Abstract
Long-term topical application of antibiotics on wounds has led to the emergence of drug-resistant bacterial infections. Antibiotic incorporation into the wound dressing requires enormous advancement of the field to ensure that the needed dose is released when the infection arises. This study synthesized a series of antimicrobial alpha-aminophosphonate derivatives, and the most effective compound was incorporated into thermoresponsive wound dressing patches. Wound dressing mats were fabricated by needleless electrospinning, and the resultant nanofiber mats were coated with a thermoresponsive eicosane/cellulose nanocrystals o/w system loaded with active alpha-aminophosphonate derivatives. Chemical, physical, thermal, and antimicrobial properties of the wound dressings were characterized wound dressings. Using SEM analysis, Nanofibers spun with 20 % w/v solutions were selected for drug-emulsion loading since they showed lower diameters with higher surface area. Furthermore, the drug-emulsion coating on the electrospun dressings improved the hydrophilicity of the wound dressings, and the thermoresponsive behavior of the mats was proved using differential scanning calorimetry data. Finally, the drug-loaded electrospun meshes were found active against tested microorganisms, and clear inhibition zones were observed. In conclusion, this novel approach of synthesizing a new family of antimicrobial molecules and their incorporation into nanofibers from renewable sources exhibits great potential for smart and innovative dressings.
Original language | English |
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Article number | 123655 |
Number of pages | 12 |
Journal | International Journal of Biological Macromolecules |
Volume | 233 |
DOIs | |
Publication status | Published - 1 Apr 2023 |
Keywords
- Antibacterial ?-amino phosphonates
- Thermoresponsive wound dressing
- Electrospinning
- Polybutylene succinate nanofibers
- ALPHA-AMINOPHOSPHONATES
- BIOMEDICAL APPLICATIONS
- INFECTION-CONTROL
- DELIVERY-SYSTEMS
- DRUG-DELIVERY
- OPTIMIZATION
- RELEASE
- SKIN