Therapeutic potential of resveratrol in obesity and type 2 diabetes: new for health benefits?

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Abstract

The number of people suffering from metabolic disorders is dramatically increasing worldwide. The need for new therapeutic strategies to combat growing epidemic of metabolic diseases is therefore also increasing. In resveratrol was discovered to be a small molecule activator of sirtuin 1 an important molecular target regulating cellular energy metabolism and mitochondrial homeostasis. Rodent studies have clearly demonstrated the of resveratrol to improve various metabolic health parameters. To date, only limited clinical data are available that have systematically health benefits of resveratrol in metabolically challenged humans. This review will give an overview of the currently available clinical studies examining the effects of resveratrol on obesity and type 2 diabetes from perspective.
Original languageEnglish
Pages (from-to)83-89
Number of pages7
JournalAnnals of the New York Academy of Sciences
Volume1290
Issue number1
DOIs
Publication statusPublished - 1 Jan 2013

Keywords

  • resveratrol
  • sirtuins
  • obesity
  • type 2 diabetes
  • mitochondria
  • 6-MONTH CALORIE RESTRICTION
  • INSULIN SENSITIVITY
  • MITOCHONDRIAL-FUNCTION
  • GLUCOSE-TOLERANCE
  • OXIDATIVE STRESS
  • SUPPLEMENTATION
  • RESISTANT
  • SIRT1
  • METABOLISM
  • EXPRESSION

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