Abstract
The number of people suffering from metabolic disorders is dramatically increasing worldwide. The need for new therapeutic strategies to combat growing epidemic of metabolic diseases is therefore also increasing. In resveratrol was discovered to be a small molecule activator of sirtuin 1 an important molecular target regulating cellular energy metabolism and mitochondrial homeostasis. Rodent studies have clearly demonstrated the of resveratrol to improve various metabolic health parameters. To date, only limited clinical data are available that have systematically health benefits of resveratrol in metabolically challenged humans. This review will give an overview of the currently available clinical studies examining the effects of resveratrol on obesity and type 2 diabetes from perspective.
| Original language | English |
|---|---|
| Pages (from-to) | 83-89 |
| Number of pages | 7 |
| Journal | Annals of the New York Academy of Sciences |
| Volume | 1290 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 1 Jan 2013 |
Keywords
- resveratrol
- sirtuins
- obesity
- type 2 diabetes
- mitochondria
- 6-MONTH CALORIE RESTRICTION
- INSULIN SENSITIVITY
- MITOCHONDRIAL-FUNCTION
- GLUCOSE-TOLERANCE
- OXIDATIVE STRESS
- SUPPLEMENTATION
- RESISTANT
- SIRT1
- METABOLISM
- EXPRESSION