Therapeutic options to overcome tumor hypoxia in radiation oncology

Esther G. C. Troost*, Lydia Koi, Ala Yaromina, Mechthild Krause

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

3 Citations (Web of Science)

Abstract

Purpose Expert review summarizing the overcome tumor cell hypoxia by treatment modification in radiation oncology.

Methods An extensive literature search regarding various means of treatment modification was performed and key papers on those modifications were included in this review article.

Results Based on the identified key papers the means to overcome hypoxia in radiation oncology were summarized in this review article, e.g., increasing levels of oxygen, combining radiotherapy with agents counteracting hypoxia, or modifying radiation treatment itself.

Conclusions This review summarizes the results of preclinical and clinical studies counteracting hypoxia and highlights the measures that have found their way into clinical practice.

Original languageEnglish
Pages (from-to)455-464
Number of pages10
JournalClinical and Translational Imaging
Volume5
Issue number5
DOIs
Publication statusPublished - Oct 2017

Keywords

  • Hypoxia
  • Radiotherapy
  • Oxygenation modification
  • Systemic agents
  • Radiation dose-escalation
  • SQUAMOUS-CELL CARCINOMA
  • ADVANCED CERVICAL-CANCER
  • III RANDOMIZED-TRIAL
  • GUIDED ADAPTIVE BRACHYTHERAPY
  • CARBONIC-ANHYDRASE IX
  • LOCALLY ADVANCED HEAD
  • NECK-CANCER
  • PHASE-III
  • IN-VIVO
  • HYPERBARIC-OXYGEN

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