Therapeutic options to overcome tumor hypoxia in radiation oncology

Esther G. C. Troost; Lydia Koi; Ala Yaromina; Mechthild Krause

doi:10.1007/s40336-017-0247-6

Therapeutic options to overcome tumor hypoxia in radiation oncology

Esther G. C. Troost^*, Lydia Koi, Ala Yaromina, Mechthild Krause

^*Corresponding author for this work

Research output: Contribution to journal › (Systematic) Review article › peer-review

Abstract

Purpose Expert review summarizing the overcome tumor cell hypoxia by treatment modification in radiation oncology.

Methods An extensive literature search regarding various means of treatment modification was performed and key papers on those modifications were included in this review article.

Results Based on the identified key papers the means to overcome hypoxia in radiation oncology were summarized in this review article, e.g., increasing levels of oxygen, combining radiotherapy with agents counteracting hypoxia, or modifying radiation treatment itself.

Conclusions This review summarizes the results of preclinical and clinical studies counteracting hypoxia and highlights the measures that have found their way into clinical practice.

Original language	English
Pages (from-to)	455-464
Number of pages	10
Journal	Clinical and Translational Imaging
Volume	5
Issue number	5
DOIs	https://doi.org/10.1007/s40336-017-0247-6
Publication status	Published - Oct 2017

Keywords

Hypoxia
Radiotherapy
Oxygenation modification
Systemic agents
Radiation dose-escalation
SQUAMOUS-CELL CARCINOMA
ADVANCED CERVICAL-CANCER
III RANDOMIZED-TRIAL
GUIDED ADAPTIVE BRACHYTHERAPY
CARBONIC-ANHYDRASE IX
LOCALLY ADVANCED HEAD
NECK-CANCER
PHASE-III
IN-VIVO
HYPERBARIC-OXYGEN

Access to Document

10.1007/s40336-017-0247-6

Cite this

@article{679bbb11a4e94d878658828a39719b2c,

title = "Therapeutic options to overcome tumor hypoxia in radiation oncology",

abstract = "Purpose Expert review summarizing the overcome tumor cell hypoxia by treatment modification in radiation oncology.Methods An extensive literature search regarding various means of treatment modification was performed and key papers on those modifications were included in this review article.Results Based on the identified key papers the means to overcome hypoxia in radiation oncology were summarized in this review article, e.g., increasing levels of oxygen, combining radiotherapy with agents counteracting hypoxia, or modifying radiation treatment itself.Conclusions This review summarizes the results of preclinical and clinical studies counteracting hypoxia and highlights the measures that have found their way into clinical practice.",

keywords = "Hypoxia, Radiotherapy, Oxygenation modification, Systemic agents, Radiation dose-escalation, SQUAMOUS-CELL CARCINOMA, ADVANCED CERVICAL-CANCER, III RANDOMIZED-TRIAL, GUIDED ADAPTIVE BRACHYTHERAPY, CARBONIC-ANHYDRASE IX, LOCALLY ADVANCED HEAD, NECK-CANCER, PHASE-III, IN-VIVO, HYPERBARIC-OXYGEN",

author = "Troost, {Esther G. C.} and Lydia Koi and Ala Yaromina and Mechthild Krause",

year = "2017",

month = oct,

doi = "10.1007/s40336-017-0247-6",

language = "English",

volume = "5",

pages = "455--464",

journal = "Clinical and Translational Imaging",

issn = "2281-5872",

publisher = "Springer",

number = "5",

}

TY - JOUR

T1 - Therapeutic options to overcome tumor hypoxia in radiation oncology

AU - Troost, Esther G. C.

AU - Koi, Lydia

AU - Yaromina, Ala

AU - Krause, Mechthild

PY - 2017/10

Y1 - 2017/10

N2 - Purpose Expert review summarizing the overcome tumor cell hypoxia by treatment modification in radiation oncology.Methods An extensive literature search regarding various means of treatment modification was performed and key papers on those modifications were included in this review article.Results Based on the identified key papers the means to overcome hypoxia in radiation oncology were summarized in this review article, e.g., increasing levels of oxygen, combining radiotherapy with agents counteracting hypoxia, or modifying radiation treatment itself.Conclusions This review summarizes the results of preclinical and clinical studies counteracting hypoxia and highlights the measures that have found their way into clinical practice.

AB - Purpose Expert review summarizing the overcome tumor cell hypoxia by treatment modification in radiation oncology.Methods An extensive literature search regarding various means of treatment modification was performed and key papers on those modifications were included in this review article.Results Based on the identified key papers the means to overcome hypoxia in radiation oncology were summarized in this review article, e.g., increasing levels of oxygen, combining radiotherapy with agents counteracting hypoxia, or modifying radiation treatment itself.Conclusions This review summarizes the results of preclinical and clinical studies counteracting hypoxia and highlights the measures that have found their way into clinical practice.

KW - Hypoxia

KW - Radiotherapy

KW - Oxygenation modification

KW - Systemic agents

KW - Radiation dose-escalation

KW - SQUAMOUS-CELL CARCINOMA

KW - ADVANCED CERVICAL-CANCER

KW - III RANDOMIZED-TRIAL

KW - GUIDED ADAPTIVE BRACHYTHERAPY

KW - CARBONIC-ANHYDRASE IX

KW - LOCALLY ADVANCED HEAD

KW - NECK-CANCER

KW - PHASE-III

KW - IN-VIVO

KW - HYPERBARIC-OXYGEN

U2 - 10.1007/s40336-017-0247-6

DO - 10.1007/s40336-017-0247-6

M3 - (Systematic) Review article

SN - 2281-5872

VL - 5

SP - 455

EP - 464

JO - Clinical and Translational Imaging

JF - Clinical and Translational Imaging

IS - 5

ER -