Theranostic and nanotheranostic probes in nuclear medicine

Natascha Drude*, Lena Tienken, Felix M. Mottaghy

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

21 Citations (Web of Science)

Abstract

In nuclear medicine, a theranostic probe describes a substance that combines diagnostic and therapeutic capabilities by radiolabeling it with different radionuclides. Next to a brief description of the different emitters (alpha, beta(+), beta(-), gamma) used for imaging and/or therapy, the aim of this review is to summarize the most commonly used theranostic probes in nuclear medicine. Another goal is to give an idea which chemical requirements need to be fulfilled for radiolabeling with either therapeutic and/or diagnostic relevant nuclides. Furthermore, a perspective is given into the field of nanotheranostics which is gaining more and more attention in nuclear medicine. The combination has been called radionanomedicine and is a very proliferative field with an enormous potential. (C) 2017 Elsevier Inc. All rights reserved.

Original languageEnglish
Pages (from-to)14-22
Number of pages9
JournalMethods
Volume130
DOIs
Publication statusPublished - 1 Nov 2017

Keywords

  • Theranostic
  • Nanotheranostic
  • Radiotherapy
  • Molecular imaging
  • Radionanomedicine
  • POSITRON-EMISSION-TOMOGRAPHY
  • RESISTANT PROSTATE-CANCER
  • TARGETED RADIONUCLIDE THERAPY
  • CARBON NANOTUBES
  • IN-VIVO
  • PRECLINICAL EVALUATION
  • RADIATION-DOSIMETRY
  • GOLD NANOPARTICLES
  • CXCR4 EXPRESSION
  • MULTIPLE-MYELOMA

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