The Y-chromosome F haplogroup contributes to the development of Barrett's esophagus-associated esophageal adenocarcinoma in a white male population

W. M. Westra, A. M. Rygiel, N. Mostafavi, G. M. J. de Wit, A. L. Roes, L. M. G. Moons, M. P. Peppelenbosch, S. Ouburg, S. A. Morre, M. Jacobs, P. D. Siersema, S. Repping, K. K. Wang, K. K. Krishnadath*

*Corresponding author for this work

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Abstract

Barrett's esophagus (BE) is a metaplastic condition of the distal esophagus, resulting from longstanding gastroesophageal reflux disease (GERD). BE predisposes for the highly malignant esophageal adenocarcinoma (EAC). Both BE and EAC have the highest frequencies in white males. Only a subset of patients with GERD develop BE, while

Original languageEnglish
Article number011
Number of pages6
JournalDiseases of the Esophagus
Volume33
Issue number9
DOIs
Publication statusPublished - Sep 2020

Keywords

  • Barrett's esophagus
  • esophageal adenocarcinoma
  • gastroesophageal reflux disease
  • genetic polymorphisms
  • Y-chromosome haplogroup
  • RISK-FACTORS
  • CIGARETTE-SMOKING
  • SUSCEPTIBILITY
  • POLYMORPHISM
  • CARCINOMA
  • MUTATION
  • DELETION
  • DISEASE

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