The vestibular implant: frequency-dependency of the electrically evoked vestibulo-ocular reflex in humans

Raymond van de Berg*, Nils Guinand, T. A. Khoa Nguyen, Maurizio Ranieri, Samuel Cavuscens, Jean-Philippe Guyot, Robert Stokroos, Herman Kingma, Angelica Perez-Fornos

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

44 Citations (Web of Science)

Abstract

The vestibulo-ocular reflex (VOR) shows frequency-dependent behavior. This study investigated whether the characteristics of the electrically evoked VOR (eVOR) elicited by a vestibular implant, showed the same frequency-dependency. Twelve vestibular electrodes implanted in seven patients with bilateral vestibular hypofunction (BVH) were tested. Stimuli consisted of amplitude-modulated electrical stimulation with a sinusoidal profile at frequencies of 0.5, 1, and 2 Hz. The main characteristics of the eVOR were evaluated and compared to the "natural" VOR characteristics measured in a group of age-matched healthy volunteers who were subjected to horizontal whole body rotations with equivalent sinusoidal velocity profiles at the same frequencies. A strong and significant effect of frequency was observed in the total peak eye velocity of the eVOR. This effect was similar to that observed in the "natural" VOR. Other characteristics of the (e)VOR (angle, habituation-index, and asymmetry) showed no significant frequency-dependent effect. In conclusion, this study demonstrates that, at least at the specific (limited) frequency range tested, responses elicited by a vestibular implant closely mimic the frequency-dependency of the "normal" vestibular system.
Original languageEnglish
Article numberUnsp 255
JournalFrontiers in systems neuroscience
Volume8
DOIs
Publication statusPublished - 20 Jan 2015

Keywords

  • vestibular implant
  • vestibular prosthesis
  • neural prosthesis
  • bilateral vestibular areflexia
  • bilateral vestibulopathy
  • vestibulo-ocular reflex

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