The use of optical coherence tomography angiography in comparing choriocapillaris recovery between two treatment strategies for multifocal choroiditis: a pilot clinical trial

Aniruddha Agarwal*, Khushdeep Abhaypal, Kanika Aggarwal, Roel J Erckens, Tos T J M Berendschot, C A B Webers, Mohit Dogra, Reema Bansal, Vishali Gupta

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

PURPOSE: To compare differences in choriocapillaris flow deficit (CC FD) in multifocal choroiditis (MFC) between two treatment arms using optical coherence tomography angiography (OCTA).

METHODS: In this prospective randomized clinical trial, patients were randomized to either Group 1 which received standard tapering dose of oral corticosteroids, or Group 2 which received additional dexamethasone implant (or intravitreal methotrexate). The patients were followed-up until 12 weeks using OCTA and other imaging tools. CC FD and visual acuity between the two groups were compared at each visit.

RESULTS: Twenty-five subjects (17 males; 25 eyes) were studied (11 eyes in Group 1). There were no differences between the visual acuity or CC FD (1.12 versus 1.08 mm 2; p = 0.86) at baseline between the groups. However, patients in Group 2 achieved better visual acuity (0.32 ± 0.23 versus 0.15 ± 0.11; p = 0.025) and CC FD (0.54 versus 0.15 mm 2; p = 0.008) at 12 weeks.

CONCLUSIONS: OCTA is a useful tool in monitoring the CC FD recovery after treatment in MFC. Patients receiving intravitreal corticosteroid/methotrexate in addition to systemic corticosteroid showed greater resolution of CC FD on OCTA compared to those receiving only oral corticosteroids.

Original languageEnglish
Article number12
Number of pages9
JournalJournal of Ophthalmic Inflammation and Infection
Volume12
Issue number1
DOIs
Publication statusPublished - 11 Mar 2022

Keywords

  • Choriocapillaris
  • Flow deficit
  • Imaging
  • Multifocal choroiditis
  • Optical coherence tomography angiography
  • SERPIGINOUS-LIKE CHOROIDITIS
  • UVEITIS
  • Uveitis

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