The use of optical coherence tomography angiography in comparing choriocapillaris recovery between two treatment strategies for multifocal choroiditis: a pilot clinical trial

Aniruddha Agarwal*, Khushdeep Abhaypal, Kanika Aggarwal, Roel J Erckens, Tos T J M Berendschot, C A B Webers, Mohit Dogra, Reema Bansal, Vishali Gupta

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Web of Science)


PURPOSE: To compare differences in choriocapillaris flow deficit (CC FD) in multifocal choroiditis (MFC) between two treatment arms using optical coherence tomography angiography (OCTA).

METHODS: In this prospective randomized clinical trial, patients were randomized to either Group 1 which received standard tapering dose of oral corticosteroids, or Group 2 which received additional dexamethasone implant (or intravitreal methotrexate). The patients were followed-up until 12 weeks using OCTA and other imaging tools. CC FD and visual acuity between the two groups were compared at each visit.

RESULTS: Twenty-five subjects (17 males; 25 eyes) were studied (11 eyes in Group 1). There were no differences between the visual acuity or CC FD (1.12 versus 1.08 mm 2; p = 0.86) at baseline between the groups. However, patients in Group 2 achieved better visual acuity (0.32 ± 0.23 versus 0.15 ± 0.11; p = 0.025) and CC FD (0.54 versus 0.15 mm 2; p = 0.008) at 12 weeks.

CONCLUSIONS: OCTA is a useful tool in monitoring the CC FD recovery after treatment in MFC. Patients receiving intravitreal corticosteroid/methotrexate in addition to systemic corticosteroid showed greater resolution of CC FD on OCTA compared to those receiving only oral corticosteroids.

Original languageEnglish
Article number12
Pages (from-to)12
Number of pages9
JournalJournal of Ophthalmic Inflammation and Infection
Issue number1
Publication statusPublished - 11 Mar 2022


  • Choriocapillaris
  • Flow deficit
  • Imaging
  • Multifocal choroiditis
  • Optical coherence tomography angiography
  • Uveitis

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