The thrombogram: monitoring thrombin generation in platelet-rich plasma

H.C. Hemker; P.L.A. Giesen; M. Ramjee; R.J. Wagenvoord; S. Béguin

doi:10.1055/S-0037-1613868

The thrombogram: monitoring thrombin generation in platelet-rich plasma

H.C. Hemker, P.L.A. Giesen, M. Ramjee, R.J. Wagenvoord, S. Béguin

CARIM School for Cardiovascular Diseases

Research output: Contribution to journal › Article › Academic › peer-review

547 Downloads (Pure)

Abstract

A method is described in which thrombin activity in clotting plasma can be monitored through the continuous measurement of the fluorescent split-product of the substrate Z-Gly-Gly-Arg-AMC. The signal is not impaired by turbidity; therefore proper measurement is not disturbed by the occurrence of a clot or the presence of platelets and direct measurement in platelet rich plasma is possible.

Original language	English
Pages (from-to)	589-591
Journal	Thrombosis and Haemostasis
Volume	83
DOIs	https://doi.org/10.1055/S-0037-1613868
Publication status	Published - 1 Jan 2000

Access to Document

10.1055/S-0037-1613868

Full TextFinal published version, 50.8 KB

Cite this

@article{c5f492d504c64d3a835a22605d52aacc,

title = "The thrombogram: monitoring thrombin generation in platelet-rich plasma",

abstract = "A method is described in which thrombin activity in clotting plasma can be monitored through the continuous measurement of the fluorescent split-product of the substrate Z-Gly-Gly-Arg-AMC. The signal is not impaired by turbidity; therefore proper measurement is not disturbed by the occurrence of a clot or the presence of platelets and direct measurement in platelet rich plasma is possible.",

author = "H.C. Hemker and P.L.A. Giesen and M. Ramjee and R.J. Wagenvoord and S. B{\'e}guin",

year = "2000",

month = jan,

day = "1",

doi = "10.1055/S-0037-1613868",

language = "English",

volume = "83",

pages = "589--591",

journal = "Thrombosis and Haemostasis",

issn = "0340-6245",

publisher = "Georg Thieme Verlag",

}

TY - JOUR

T1 - The thrombogram: monitoring thrombin generation in platelet-rich plasma

AU - Hemker, H.C.

AU - Giesen, P.L.A.

AU - Ramjee, M.

AU - Wagenvoord, R.J.

AU - Béguin, S.

PY - 2000/1/1

Y1 - 2000/1/1

N2 - A method is described in which thrombin activity in clotting plasma can be monitored through the continuous measurement of the fluorescent split-product of the substrate Z-Gly-Gly-Arg-AMC. The signal is not impaired by turbidity; therefore proper measurement is not disturbed by the occurrence of a clot or the presence of platelets and direct measurement in platelet rich plasma is possible.

AB - A method is described in which thrombin activity in clotting plasma can be monitored through the continuous measurement of the fluorescent split-product of the substrate Z-Gly-Gly-Arg-AMC. The signal is not impaired by turbidity; therefore proper measurement is not disturbed by the occurrence of a clot or the presence of platelets and direct measurement in platelet rich plasma is possible.

U2 - 10.1055/S-0037-1613868

DO - 10.1055/S-0037-1613868

M3 - Article

SN - 0340-6245

VL - 83

SP - 589

EP - 591

JO - Thrombosis and Haemostasis

JF - Thrombosis and Haemostasis

ER -