The thrombogram: monitoring thrombin generation in platelet-rich plasma

H.C. Hemker, P.L.A. Giesen, M. Ramjee, R.J. Wagenvoord, S. Béguin

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Abstract

A method is described in which thrombin activity in clotting plasma can be monitored through the continuous measurement of the fluorescent split-product of the substrate Z-Gly-Gly-Arg-AMC. The signal is not impaired by turbidity; therefore proper measurement is not disturbed by the occurrence of a clot or the presence of platelets and direct measurement in platelet rich plasma is possible.
Original languageEnglish
Pages (from-to)589-591
JournalThrombosis and Haemostasis
Volume83
DOIs
Publication statusPublished - 1 Jan 2000

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