The subthalamic nucleus: From response selection to execution

S.K. Tan; Y. Temel; A. Blokland; H.W. Steinbusch; V. Vandewalle

doi:10.1016/j.jchemneu.2006.01.001

The subthalamic nucleus: From response selection to execution

S.K. Tan, Y. Temel^*, A. Blokland, H.W. Steinbusch, V. Vandewalle

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The involvement of the subthalamic nucleus in physiological and pathological motor behaviour has now largely been established. Clinical observations in patients suffering from Parkinson disease treated with Deep Brain Stimulation of the STN show that these patients can suffer from postoperative changes in non-motor behaviour mainly involving alterations in cognitive functions. The involvement of the STN in cognition has initially been demonstrated by non-human studies investigating the effects of STN lesions and stimulations on cognitive parameters. In the present review, we discuss the findings of these preclinical studies on cognitive parameters and outline the anatomical and functional place of the STN in the basal ganglia cognitive circuit.

Original language	English
Pages (from-to)	155-161
Journal	Journal of Chemical Neuroanatomy
Volume	31
DOIs	https://doi.org/10.1016/j.jchemneu.2006.01.001
Publication status	Published - 1 Jan 2006

Access to Document

10.1016/j.jchemneu.2006.01.001

Cite this

@article{ba6a8d353cdb4402ae299b9487e4a62a,

title = "The subthalamic nucleus: From response selection to execution",

abstract = "The involvement of the subthalamic nucleus in physiological and pathological motor behaviour has now largely been established. Clinical observations in patients suffering from Parkinson disease treated with Deep Brain Stimulation of the STN show that these patients can suffer from postoperative changes in non-motor behaviour mainly involving alterations in cognitive functions. The involvement of the STN in cognition has initially been demonstrated by non-human studies investigating the effects of STN lesions and stimulations on cognitive parameters. In the present review, we discuss the findings of these preclinical studies on cognitive parameters and outline the anatomical and functional place of the STN in the basal ganglia cognitive circuit. ",

author = "S.K. Tan and Y. Temel and A. Blokland and H.W. Steinbusch and V. Vandewalle",

year = "2006",

month = jan,

day = "1",

doi = "10.1016/j.jchemneu.2006.01.001",

language = "English",

volume = "31",

pages = "155--161",

journal = "Journal of Chemical Neuroanatomy",

issn = "0891-0618",

publisher = "Elsevier Science",

}

TY - JOUR

T1 - The subthalamic nucleus: From response selection to execution

AU - Tan, S.K.

AU - Temel, Y.

AU - Blokland, A.

AU - Steinbusch, H.W.

AU - Vandewalle, V.

PY - 2006/1/1

Y1 - 2006/1/1

N2 - The involvement of the subthalamic nucleus in physiological and pathological motor behaviour has now largely been established. Clinical observations in patients suffering from Parkinson disease treated with Deep Brain Stimulation of the STN show that these patients can suffer from postoperative changes in non-motor behaviour mainly involving alterations in cognitive functions. The involvement of the STN in cognition has initially been demonstrated by non-human studies investigating the effects of STN lesions and stimulations on cognitive parameters. In the present review, we discuss the findings of these preclinical studies on cognitive parameters and outline the anatomical and functional place of the STN in the basal ganglia cognitive circuit.

AB - The involvement of the subthalamic nucleus in physiological and pathological motor behaviour has now largely been established. Clinical observations in patients suffering from Parkinson disease treated with Deep Brain Stimulation of the STN show that these patients can suffer from postoperative changes in non-motor behaviour mainly involving alterations in cognitive functions. The involvement of the STN in cognition has initially been demonstrated by non-human studies investigating the effects of STN lesions and stimulations on cognitive parameters. In the present review, we discuss the findings of these preclinical studies on cognitive parameters and outline the anatomical and functional place of the STN in the basal ganglia cognitive circuit.

U2 - 10.1016/j.jchemneu.2006.01.001

DO - 10.1016/j.jchemneu.2006.01.001

M3 - Article

C2 - 16473494

SN - 0891-0618

VL - 31

SP - 155

EP - 161

JO - Journal of Chemical Neuroanatomy

JF - Journal of Chemical Neuroanatomy

ER -