The spectrum of diabetic foot disease: etiological considerations and prediction of outcome

Kristy M.C. Pickwell

Research output: ThesisDoctoral ThesisExternal prepared


A foot problem caused by diabetes may lead to foot amputation. Nerve damage associated with diabetes may prevent inflammatory reactions from being initialised properly. As a result, the severity of diabetic foot disease may be underestimated. Nerve damage may also prevent inflammatory reactions from being timely inhibited. Both situations may lead to severe tissue damage and amputation. In several cases, including infection and arterial occlusions in patients with diabetic foot disease, it is shown that the chance of cure and risk of amputation can be predicted based on easily obtainable data, allowing the best treatment for each individual to be chosen.
Original languageEnglish
Awarding Institution
  • Maastricht University
  • Schaper, Nicolaas, Supervisor
  • Kars, Marleen, Co-Supervisor
  • Siersma, V.D., Co-Supervisor, External person
Award date24 Nov 2017
Publication statusPublished - 2017


  • diabetic foot
  • etiology
  • outcome
  • amputation
  • infection
  • quality of life
  • diabetic
  • neuropathy
  • peripheral vascular disease
  • Charcot foot

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