The small fiber neuropathy NaV1.7 I228M mutation: impaired neurite integrity via bioenergetic and mitotoxic mechanisms, and protection by dexpramipexole

Seong-il Lee, Janneke G. J. Hoeijmakers, Catharina G. Faber, Ingemar S. J. Merkies, Giuseppe Lauria, Stephen G. Waxman*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Pages (from-to)645-657
Number of pages13
JournalJournal of Neurophysiology
Volume123
Issue number2
DOIs
Publication statusPublished - Feb 2020

Keywords

  • bioenergetics
  • gain of function
  • mitotoxicity
  • NaV1.7
  • neuropathy
  • ATP LEVELS
  • AXONAL DEGENERATION
  • ENERGY-METABOLISM
  • SODIUM-CHANNELS
  • NERVE-FIBERS
  • MITOCHONDRIAL
  • NEURONS
  • DYSFUNCTION
  • PLASTICITY
  • SYMPTOMS

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