TY - JOUR
T1 - The SERPINE2 gene is associated with chronic obstructive pulmonary disease in two large populations.
AU - Zhu, G.
AU - Warren, L.
AU - Aponte, J.
AU - Gulsvik, A.
AU - Bakke, P.
AU - Anderson, W.H.
AU - Lomas, D.A.
AU - Silverman, E.K.
AU - Pillai, S.G.
AU - International COPD Genetics Network Investigators, (incl. E. Wouters)
PY - 2007/1/1
Y1 - 2007/1/1
N2 - Chronic obstructive pulmonary disease (COPD) is a complex disease influenced by multiple genes and environmental factors. A region on chromosome 2q has been shown to be linked to COPD. A positional candidate gene from the chromosome 2q region SERPINE2 (Serpin peptidase inhibitor, clade E [nexin, plasminogen activator inhibitor type 1], member 2), was previously evaluated as a susceptibility gene for COPD in two association studies, but the results were contradictory.To identify the relationship between SERPINE2 polymorphisms and COPD-related phenotypes using family-based and case-control association studies.In the present study, we genotyped 25 single nucleotide polymorphisms (SNPs) from SERPINE2 and analyzed qualitative and quantitative COPD phenotypes in 635 pedigrees with 1,910 individuals and an independent case-control population that included 973 COPD cases and 956 control subjects. The family data were analyzed using family-based association tests. The case-control data were analyzed using logistic regression and linear models.Six SNPs demonstrated significant associations with COPD phenotypes in the family-based association analysis (0.0016
AB - Chronic obstructive pulmonary disease (COPD) is a complex disease influenced by multiple genes and environmental factors. A region on chromosome 2q has been shown to be linked to COPD. A positional candidate gene from the chromosome 2q region SERPINE2 (Serpin peptidase inhibitor, clade E [nexin, plasminogen activator inhibitor type 1], member 2), was previously evaluated as a susceptibility gene for COPD in two association studies, but the results were contradictory.To identify the relationship between SERPINE2 polymorphisms and COPD-related phenotypes using family-based and case-control association studies.In the present study, we genotyped 25 single nucleotide polymorphisms (SNPs) from SERPINE2 and analyzed qualitative and quantitative COPD phenotypes in 635 pedigrees with 1,910 individuals and an independent case-control population that included 973 COPD cases and 956 control subjects. The family data were analyzed using family-based association tests. The case-control data were analyzed using logistic regression and linear models.Six SNPs demonstrated significant associations with COPD phenotypes in the family-based association analysis (0.0016
U2 - 10.1164/rccm.200611-1723OC
DO - 10.1164/rccm.200611-1723OC
M3 - Article
C2 - 17446335
SN - 1073-449X
VL - 176
SP - 167
EP - 173
JO - American Journal of Respiratory and Critical Care Medicine
JF - American Journal of Respiratory and Critical Care Medicine
ER -