TY - JOUR
T1 - The "Sarcopenia and Physical fRailty IN older people multi-componenT Treatment strategies" (SPRINTT)
T2 - Case finding, screening and characteristics of eligible participants
AU - Marzetti, Emanuele
AU - Cesari, Matteo
AU - Calvani, Riccardo
AU - Msihid, Jerome
AU - Tosato, Matteo
AU - Rodriguez-Manas, Leocadio
AU - Lattanzio, Fabrizia
AU - Cherubini, Antonio
AU - Bejuit, Raphael
AU - Bari, Mauro Di
AU - Maggio, Marcello
AU - Vellas, Bruno
AU - Dantoine, Thierry
AU - Cruz-Jentoft, Alfonso J.
AU - Sieber, Cornel C.
AU - Freiberger, Ellen
AU - Skalska, Anna
AU - Grodzicki, Tomasz
AU - Sinclair, Alan J.
AU - Topinkova, Eva
AU - Ryznarova, Ingrid
AU - Strandberg, Timo
AU - Schols, Annemie M. W. J.
AU - Schols, Jos M. G. A.
AU - Roller-Wirnsberger, Regina
AU - Jonsson, Palmi
AU - Ramel, Alfons
AU - Del Signore, Susanna
AU - Pahor, Marco
AU - Roubenoff, Ronenn
AU - Bernabei, Roberto
AU - Landi, Francesco
AU - SPRINTT Consortium
PY - 2018/11
Y1 - 2018/11
N2 - Background: The ongoing "Sarcopenia and Physical fRailty IN older people: multi-componenT Treatment strategies (SPRINTT)"randomized controlled trial (RCT) is testing the efficacy of a multicomponent intervention in the prevention of mobility disability in older adults with physical frailty & sarcopenia (PF& S). Here, we describe the procedures followed for PF& S case finding and screening of candidate participants for the SPRINTT RCT. We also illustrate the main demographic and clinical characteristics of eligible screenees.Methods: The identification of PF& S was based on the co-occurrence of three defining elements: (1) reduced physical performance (defined as a score on the Short Physical Performance Battery between 3 and 9); (2) low muscle mass according to the criteria released by the Foundation for the National Institutes of Health; and (3) absence of mobility disability (defined as ability to complete the 400-m walk test in 15 min). SPRINTT was advertised through a variety of means. Site-specific case finding strategies were developed to accommodate the variability across centers in catchment area characteristics and access to the target population. A quick "participant profiling"questionnaire was devised to facilitate PF& S case finding.Results: During approximately 22 months, 12,358 prescreening interviews were completed in 17 SPRINTT sites resulting in 6710 clinic screening visits. Eventually, 1566 candidates were found to be eligible for participating in the SPRINTT RCT. Eligible screenees showed substantial physical function impairment and comorbidity burden. In most centers, project advertisement through mass media was the most rewarding case finding strategy.Conclusion: PF& S case finding in the community is a challenging, but feasible task. Although largely autonomous in daily life activities, older adults with PF& S suffer from significant functional impairment and comorbidity. This subset of the older population is therefore at high risk for disability and other negative health-related events. Key strategies to consider for successfully intercepting at-risk older adults should focus on mass communication methods.
AB - Background: The ongoing "Sarcopenia and Physical fRailty IN older people: multi-componenT Treatment strategies (SPRINTT)"randomized controlled trial (RCT) is testing the efficacy of a multicomponent intervention in the prevention of mobility disability in older adults with physical frailty & sarcopenia (PF& S). Here, we describe the procedures followed for PF& S case finding and screening of candidate participants for the SPRINTT RCT. We also illustrate the main demographic and clinical characteristics of eligible screenees.Methods: The identification of PF& S was based on the co-occurrence of three defining elements: (1) reduced physical performance (defined as a score on the Short Physical Performance Battery between 3 and 9); (2) low muscle mass according to the criteria released by the Foundation for the National Institutes of Health; and (3) absence of mobility disability (defined as ability to complete the 400-m walk test in 15 min). SPRINTT was advertised through a variety of means. Site-specific case finding strategies were developed to accommodate the variability across centers in catchment area characteristics and access to the target population. A quick "participant profiling"questionnaire was devised to facilitate PF& S case finding.Results: During approximately 22 months, 12,358 prescreening interviews were completed in 17 SPRINTT sites resulting in 6710 clinic screening visits. Eventually, 1566 candidates were found to be eligible for participating in the SPRINTT RCT. Eligible screenees showed substantial physical function impairment and comorbidity burden. In most centers, project advertisement through mass media was the most rewarding case finding strategy.Conclusion: PF& S case finding in the community is a challenging, but feasible task. Although largely autonomous in daily life activities, older adults with PF& S suffer from significant functional impairment and comorbidity. This subset of the older population is therefore at high risk for disability and other negative health-related events. Key strategies to consider for successfully intercepting at-risk older adults should focus on mass communication methods.
KW - Physical performance
KW - Mobility disability
KW - Functional impairment
KW - Recruitment
KW - Prevention
KW - Skeletal muscle
KW - LOWER-EXTREMITY FUNCTION
KW - AGE-RELATED-CHANGES
KW - MOBILITY DISABILITY
KW - SKELETAL-MUSCLE
KW - HEALTH ABC
KW - WALK TEST
KW - ADULTS
KW - PERFORMANCE
KW - OBESITY
KW - STRENGTH
U2 - 10.1016/j.exger.2018.09.017
DO - 10.1016/j.exger.2018.09.017
M3 - Article
C2 - 30261246
SN - 0531-5565
VL - 113
SP - 48
EP - 57
JO - Experimental Gerontology
JF - Experimental Gerontology
ER -