The Rs12569232 SNP Association with Vogt-Koyanagi-Harada Disease and Behcet's Disease is Probably Mediated by Regulation of Linc00467 Expression

Q.F. Wang, S.L. Yi, Z.Y. Du, X.Y. Huang, J. Xu, Q.F. Cao, G.N. Su, A. Kijlstra, P.Z. Yang*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Web of Science)


Purpose: To investigate whether the rs12569232 SNP association with Vogt-Koyanagi-Harada disease and Behcet's disease is mediated by regulation of Linc00467 expression. Methods: The expression of linc00467 was detected by real-time PCR. Adenovirus carrying the linc00467 was transduced into CD4(+)T cells and the effect on cell viability was measured by the CCK-8 test. Human proteome microarray and starBase 2.0 were used to identify the binding proteins of linc00467 and RNA Immunoprecipitation (RIP) was used to confirm the identity of bound proteins. Results: The rs12569232 was associated with the expression of linc00467. The expression of linc00467 was up-regulated in PBMCs and CD4(+)T cells from VKH disease and BD patients. Over-expression of linc00467 increased cell viability of CD4(+)T cells. HUR was the common binding protein identified by the two methods and confirmed by RIP. Conclusions: The rs12569232 association with VKH disease and BD may be mediated via regulating the expression of linc00467.
Original languageEnglish
Pages (from-to)1464-1470
Number of pages7
JournalOcular Immunology and Inflammation
Issue number7-8
Early online date10 May 2020
Publication statusPublished - 17 Nov 2021


  • behcet's disease
  • cd4(+)t cells
  • hur
  • insights
  • lincrna
  • single nucleotide polymorphism
  • vogt-koyanagi-harada disease
  • Vogt-Koyanagi-Harada disease
  • HUR
  • Cd4(+)T cells
  • Behcet's disease
  • lincRNA

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