The Role of Vitamins in Neurodegenerative Disease: An Update

S.N. Rai; P. Singh; H.W.M. Steinbusch; E. Vamanu; G. Ashraf; M.P. Singh

doi:10.3390/biomedicines9101284

The Role of Vitamins in Neurodegenerative Disease: An Update

S.N. Rai, P. Singh^*, H.W.M. Steinbusch, E. Vamanu^*, G. Ashraf, M.P. Singh^*

^*Corresponding author for this work

Research output: Contribution to journal › (Systematic) Review article › peer-review

Abstract

Acquiring the recommended daily allowance of vitamins is crucial for maintaining homeostatic balance in humans and other animals. A deficiency in or dysregulation of vitamins adversely affects the neuronal metabolism, which may lead to neurodegenerative diseases. In this article, we discuss how novel vitamin-based approaches aid in attenuating abnormal neuronal functioning in neurodegeneration-based brain diseases such as Alzheimer's disease, Parkinson's disease, Huntington's disease, Amyotrophic lateral sclerosis, and Prion disease. Vitamins show their therapeutic activity in Parkinson's disease by antioxidative and anti-inflammatory activity. In addition, different water- and lipid-soluble vitamins have also prevented amyloid beta and tau pathology. On the other hand, some results also show no correlation between vitamin action and the prevention of neurodegenerative diseases. Some vitamins also exhibit toxic activity too. This review discusses both the beneficial and null effects of vitamin supplementation for neurological disorders. The detailed mechanism of action of both water- and lipid-soluble vitamins is addressed in the manuscript. Hormesis is also an essential factor that is very helpful to determine the effective dose of vitamins. PubMed, Google Scholar, Web of Science, and Scopus were employed to conduct the literature search of original articles, review articles, and meta-analyses.</p>

Original language	English
Article number	1284
Number of pages	30
Journal	Biomedicines
Volume	9
Issue number	10
DOIs	https://doi.org/10.3390/biomedicines9101284
Publication status	Published - 1 Oct 2021

Keywords

vitamins
neurodegenerative disease
Parkinson's disease
Alzheimer's disease
Huntington disease
Prion disease
NERVE GROWTH-FACTOR
ENDOPLASMIC-RETICULUM STRESS
BLOOD-BRAIN-BARRIER
PARKINSONS-DISEASE
MULTIPLE-SCLEROSIS
RETINOIC ACID
ALZHEIMERS-DISEASE
OXIDATIVE STRESS
HUNTINGTONS-DISEASE
ALPHA-TOCOPHEROL

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Cite this

@article{75483ea940c44f28b74937614cd4feb6,

title = "The Role of Vitamins in Neurodegenerative Disease: An Update",

abstract = "Acquiring the recommended daily allowance of vitamins is crucial for maintaining homeostatic balance in humans and other animals. A deficiency in or dysregulation of vitamins adversely affects the neuronal metabolism, which may lead to neurodegenerative diseases. In this article, we discuss how novel vitamin-based approaches aid in attenuating abnormal neuronal functioning in neurodegeneration-based brain diseases such as Alzheimer's disease, Parkinson's disease, Huntington's disease, Amyotrophic lateral sclerosis, and Prion disease. Vitamins show their therapeutic activity in Parkinson's disease by antioxidative and anti-inflammatory activity. In addition, different water- and lipid-soluble vitamins have also prevented amyloid beta and tau pathology. On the other hand, some results also show no correlation between vitamin action and the prevention of neurodegenerative diseases. Some vitamins also exhibit toxic activity too. This review discusses both the beneficial and null effects of vitamin supplementation for neurological disorders. The detailed mechanism of action of both water- and lipid-soluble vitamins is addressed in the manuscript. Hormesis is also an essential factor that is very helpful to determine the effective dose of vitamins. PubMed, Google Scholar, Web of Science, and Scopus were employed to conduct the literature search of original articles, review articles, and meta-analyses.",

keywords = "vitamins, neurodegenerative disease, Parkinson's disease, Alzheimer's disease, Huntington disease, Prion disease, NERVE GROWTH-FACTOR, ENDOPLASMIC-RETICULUM STRESS, BLOOD-BRAIN-BARRIER, PARKINSONS-DISEASE, MULTIPLE-SCLEROSIS, RETINOIC ACID, ALZHEIMERS-DISEASE, OXIDATIVE STRESS, HUNTINGTONS-DISEASE, ALPHA-TOCOPHEROL",

author = "S.N. Rai and P. Singh and H.W.M. Steinbusch and E. Vamanu and G. Ashraf and M.P. Singh",

note = "Funding Information: Acknowledgments: The authors also acknowledge the University grant Commission D.S. Kothari Postdoctoral Fellowship to Sachchida Nand Rai (Reference #: F.4-2/2006 (BSR)/BL/19-20/0032) and The Deanship of Scientific Research (DSR) at King Abdulaziz University, Jeddah, Saudi Arabia has funded this project under grant no. (FP-81-42). The authors also would like to acknowledge Bio-render (https://app.biorender.com/biorender-templates (accessed on 20 April 2020)) for providing an efficient platform to create all the figures. Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2021",

month = oct,

day = "1",

doi = "10.3390/biomedicines9101284",

language = "English",

volume = "9",

journal = "Biomedicines",

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TY - JOUR

T1 - The Role of Vitamins in Neurodegenerative Disease: An Update

AU - Rai, S.N.

AU - Singh, P.

AU - Steinbusch, H.W.M.

AU - Vamanu, E.

AU - Ashraf, G.

AU - Singh, M.P.

N1 - Funding Information: Acknowledgments: The authors also acknowledge the University grant Commission D.S. Kothari Postdoctoral Fellowship to Sachchida Nand Rai (Reference #: F.4-2/2006 (BSR)/BL/19-20/0032) and The Deanship of Scientific Research (DSR) at King Abdulaziz University, Jeddah, Saudi Arabia has funded this project under grant no. (FP-81-42). The authors also would like to acknowledge Bio-render (https://app.biorender.com/biorender-templates (accessed on 20 April 2020)) for providing an efficient platform to create all the figures. Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2021/10/1

Y1 - 2021/10/1

N2 - Acquiring the recommended daily allowance of vitamins is crucial for maintaining homeostatic balance in humans and other animals. A deficiency in or dysregulation of vitamins adversely affects the neuronal metabolism, which may lead to neurodegenerative diseases. In this article, we discuss how novel vitamin-based approaches aid in attenuating abnormal neuronal functioning in neurodegeneration-based brain diseases such as Alzheimer's disease, Parkinson's disease, Huntington's disease, Amyotrophic lateral sclerosis, and Prion disease. Vitamins show their therapeutic activity in Parkinson's disease by antioxidative and anti-inflammatory activity. In addition, different water- and lipid-soluble vitamins have also prevented amyloid beta and tau pathology. On the other hand, some results also show no correlation between vitamin action and the prevention of neurodegenerative diseases. Some vitamins also exhibit toxic activity too. This review discusses both the beneficial and null effects of vitamin supplementation for neurological disorders. The detailed mechanism of action of both water- and lipid-soluble vitamins is addressed in the manuscript. Hormesis is also an essential factor that is very helpful to determine the effective dose of vitamins. PubMed, Google Scholar, Web of Science, and Scopus were employed to conduct the literature search of original articles, review articles, and meta-analyses.

AB - Acquiring the recommended daily allowance of vitamins is crucial for maintaining homeostatic balance in humans and other animals. A deficiency in or dysregulation of vitamins adversely affects the neuronal metabolism, which may lead to neurodegenerative diseases. In this article, we discuss how novel vitamin-based approaches aid in attenuating abnormal neuronal functioning in neurodegeneration-based brain diseases such as Alzheimer's disease, Parkinson's disease, Huntington's disease, Amyotrophic lateral sclerosis, and Prion disease. Vitamins show their therapeutic activity in Parkinson's disease by antioxidative and anti-inflammatory activity. In addition, different water- and lipid-soluble vitamins have also prevented amyloid beta and tau pathology. On the other hand, some results also show no correlation between vitamin action and the prevention of neurodegenerative diseases. Some vitamins also exhibit toxic activity too. This review discusses both the beneficial and null effects of vitamin supplementation for neurological disorders. The detailed mechanism of action of both water- and lipid-soluble vitamins is addressed in the manuscript. Hormesis is also an essential factor that is very helpful to determine the effective dose of vitamins. PubMed, Google Scholar, Web of Science, and Scopus were employed to conduct the literature search of original articles, review articles, and meta-analyses.

KW - vitamins

KW - neurodegenerative disease

KW - Parkinson's disease

KW - Alzheimer's disease

KW - Huntington disease

KW - Prion disease

KW - NERVE GROWTH-FACTOR

KW - ENDOPLASMIC-RETICULUM STRESS

KW - BLOOD-BRAIN-BARRIER

KW - PARKINSONS-DISEASE

KW - MULTIPLE-SCLEROSIS

KW - RETINOIC ACID

KW - ALZHEIMERS-DISEASE

KW - OXIDATIVE STRESS

KW - HUNTINGTONS-DISEASE

KW - ALPHA-TOCOPHEROL

U2 - 10.3390/biomedicines9101284

DO - 10.3390/biomedicines9101284

M3 - (Systematic) Review article

C2 - 34680401

SN - 2227-9059

VL - 9

JO - Biomedicines

JF - Biomedicines

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M1 - 1284

ER -