TY - JOUR
T1 - The Role of Urinary Microbiota in Lower Urinary Tract Dysfunction
T2 - A Systematic Review
AU - Antunes-Lopes, Tiago
AU - Vale, Luis
AU - Coelho, Ana Margarida
AU - Silva, Carlos
AU - Rieken, Malte
AU - Geavlete, Bogdan
AU - Rashid, Tina
AU - Rahnama'i, Sajjad M.
AU - Cornu, Jean Nicolas
AU - Marcelissen, Tom
AU - EAU Young Academic Urologists (YAU) Functional Urology Working Group
N1 - Publisher Copyright:
© 2018
PY - 2020/3/15
Y1 - 2020/3/15
N2 - Context: Until 2012, the urinary tract of healthy individuals was considered to be sterile. The advent of metagenomic sequencing revealed a unique urinary microbiota (UM). This paradigm shift appears to have prolific implications in the etiology of several functional lower urinary tract (LUT) disorders.Objective: To systematically summarize recent data on the role of UM in LUT dysfunction.Evidence acquisition: We performed a critical review according to the Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA) statement. We conducted a search on PubMed/MEDLINE and SCOPUS with the following MESH terms/keywords: "Microbiome OR Microbiota AND (urinary disorder OR urinary tract symptom OR overactive bladder OR urinary incontinence OR interstitial cystitis OR chronic prostatitis)." The range of search was placed between January 2010 and April 2018, and articles with no full text available or those not written in English were excluded. All retrieved papers were first reviewed by title and abstract, yielding a total of 303 papers. Additional manuscripts, such as those referenced by reviews, were further included. Thirty-six publications were included.Evidence synthesis: Analysis by 16S rRNA sequence and expanded quantitative urine culture provided evidence for the presence of live bacteria in urine, nondetectable by standard culture protocols. Moreover, differences in the UM between healthy individuals and patients with LUT dysfunction were demonstrated.Conclusion: In the near future, urologists must consider urinary dysbiosis as a possible cause of different functional LUT disorders, with potential clinical implications in their diagnosis and treatment.Patient summary: Development of metagenomic sequencing revealed a unique urinary microbiota nondetectable by standard culture protocols. This systematic review summarizing recent data on the role of urinary microbiota in lower urinary tract (LUT) dysfunction supports urinary dysbiosis as a possible cause of different functional LUT disorders. (C) 2018 Published by Elsevier B.V. on behalf of European Association of Urology.
AB - Context: Until 2012, the urinary tract of healthy individuals was considered to be sterile. The advent of metagenomic sequencing revealed a unique urinary microbiota (UM). This paradigm shift appears to have prolific implications in the etiology of several functional lower urinary tract (LUT) disorders.Objective: To systematically summarize recent data on the role of UM in LUT dysfunction.Evidence acquisition: We performed a critical review according to the Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA) statement. We conducted a search on PubMed/MEDLINE and SCOPUS with the following MESH terms/keywords: "Microbiome OR Microbiota AND (urinary disorder OR urinary tract symptom OR overactive bladder OR urinary incontinence OR interstitial cystitis OR chronic prostatitis)." The range of search was placed between January 2010 and April 2018, and articles with no full text available or those not written in English were excluded. All retrieved papers were first reviewed by title and abstract, yielding a total of 303 papers. Additional manuscripts, such as those referenced by reviews, were further included. Thirty-six publications were included.Evidence synthesis: Analysis by 16S rRNA sequence and expanded quantitative urine culture provided evidence for the presence of live bacteria in urine, nondetectable by standard culture protocols. Moreover, differences in the UM between healthy individuals and patients with LUT dysfunction were demonstrated.Conclusion: In the near future, urologists must consider urinary dysbiosis as a possible cause of different functional LUT disorders, with potential clinical implications in their diagnosis and treatment.Patient summary: Development of metagenomic sequencing revealed a unique urinary microbiota nondetectable by standard culture protocols. This systematic review summarizing recent data on the role of urinary microbiota in lower urinary tract (LUT) dysfunction supports urinary dysbiosis as a possible cause of different functional LUT disorders. (C) 2018 Published by Elsevier B.V. on behalf of European Association of Urology.
KW - Microbiota
KW - Lower urinary tract symptoms
KW - Overactive bladder
KW - Interstitial cystitis
KW - Chronic prostatitis
KW - PELVIC PAIN SYNDROME
KW - CLASSIFICATION
KW - INCONTINENCE
KW - SYMPTOMS
KW - BLADDER
KW - HEALTH
U2 - 10.1016/j.euf.2018.09.011
DO - 10.1016/j.euf.2018.09.011
M3 - (Systematic) Review article
C2 - 30270128
SN - 2405-4569
VL - 6
SP - 361
EP - 369
JO - European Urology Focus
JF - European Urology Focus
IS - 2
ER -