The role of the skeletal muscle in the early onset of the metabolic syndrome : a nutrigenomics approach

J. de Wilde

Research output: ThesisDoctoral ThesisInternal

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The muscle plays an important role in the development of the metabolic syndrome (metabolic disease due to an imbalance between eating and exercising). The worldwide increase of the metabolic syndrome is caused by high-fat food. This dissertation describes the effect of high-fat food on the muscle by molecular changes at the gene, protein and fat metabolite level. High-fat food causes molecular changes in the muscle that indicate an increase of the capacity of the fat metabolism. By actually measuring the fat metabolism the molecular changes were confirmed. These findings show how molecular research can be successfully integrated with more applied research.
(This research was financed by the Nutrigenomics Consortium of TI Food and Nutrition).
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • Maastricht University
  • Mariman, Edwin, Supervisor
  • Smit, Egbert, Co-Supervisor
Award date17 Dec 2010
Place of PublicationMaastricht
Publication statusPublished - 1 Jan 2010


  • metabolic syndrome
  • muscle
  • high-fat food

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