Abstract
Vascular remodeling participates in the development and progression of cardiovascular conditions such as hypertension, atherosclerosis, and aneurysm. This process is fine-tuned by neurohumoral regulatory pathways: the renin-angiotensin system (RAS), being one of the most important. Chronic RAS activation, via AT1 receptor (AT1R) stimulation, sets on a series of proproliferative, profibrotic, and proinflammatory signals that promote vascular remodeling and lead to adverse cardiovascular outcomes. The prevention of these outcomes after the blockade of this "deleterious" RAS might be at least in part mediated by the activation of the "protective" RAS. The "protective" RAS involves the AT2 receptor (AT2R) with antiproliferative, antifibrotic, anti-inflammatory, and antioxidant effects. In this chapter, we review the available evidence for the role of AT2R in vascular remodeling in hypertension, atherosclerosis, or aneurysm development.
Original language | English |
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Title of host publication | The Protective Arm of the Renin Angiotensin System (RAS), Functional Aspects and Therapeutic Implications |
Editors | T. Unger, M. Steckelings, R.A. Souza dos Santos |
Publisher | Academic Press |
Pages | 89-95 |
Edition | 1 |
ISBN (Electronic) | 9780128014851 |
ISBN (Print) | 9780128013649 |
DOIs | |
Publication status | Published - 2015 |