The Role of the AT2R in Vascular Remodeling

S. Foulquier; L. Paulis

doi:10.1016/B978-0-12-801364-9.00012-2

The Role of the AT2R in Vascular Remodeling

S. Foulquier, L. Paulis

Pathologie

Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic

Abstract

Vascular remodeling participates in the development and progression of cardiovascular conditions such as hypertension, atherosclerosis, and aneurysm. This process is fine-tuned by neurohumoral regulatory pathways: the renin-angiotensin system (RAS), being one of the most important. Chronic RAS activation, via AT₁ receptor (AT₁R) stimulation, sets on a series of proproliferative, profibrotic, and proinflammatory signals that promote vascular remodeling and lead to adverse cardiovascular outcomes. The prevention of these outcomes after the blockade of this "deleterious" RAS might be at least in part mediated by the activation of the "protective" RAS. The "protective" RAS involves the AT₂ receptor (AT₂R) with antiproliferative, antifibrotic, anti-inflammatory, and antioxidant effects. In this chapter, we review the available evidence for the role of AT₂R in vascular remodeling in hypertension, atherosclerosis, or aneurysm development.

Original language	English
Title of host publication	The Protective Arm of the Renin Angiotensin System (RAS), Functional Aspects and Therapeutic Implications
Editors	T. Unger, M. Steckelings, R.A. Souza dos Santos
Publisher	Academic Press
Pages	89-95
Edition	1
ISBN (Electronic)	9780128014851
ISBN (Print)	9780128013649
DOIs	https://doi.org/10.1016/B978-0-12-801364-9.00012-2
Publication status	Published - 2015

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10.1016/B978-0-12-801364-9.00012-2

Cite this

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AB - Vascular remodeling participates in the development and progression of cardiovascular conditions such as hypertension, atherosclerosis, and aneurysm. This process is fine-tuned by neurohumoral regulatory pathways: the renin-angiotensin system (RAS), being one of the most important. Chronic RAS activation, via AT1 receptor (AT1R) stimulation, sets on a series of proproliferative, profibrotic, and proinflammatory signals that promote vascular remodeling and lead to adverse cardiovascular outcomes. The prevention of these outcomes after the blockade of this "deleterious" RAS might be at least in part mediated by the activation of the "protective" RAS. The "protective" RAS involves the AT2 receptor (AT2R) with antiproliferative, antifibrotic, anti-inflammatory, and antioxidant effects. In this chapter, we review the available evidence for the role of AT2R in vascular remodeling in hypertension, atherosclerosis, or aneurysm development.

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BT - The Protective Arm of the Renin Angiotensin System (RAS), Functional Aspects and Therapeutic Implications

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The Role of the AT2R in Vascular Remodeling

Abstract

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