The Role of Ribonuclease 1 and Ribonuclease Inhibitor 1 in Acute Kidney Injury after Open and Endovascular Thoracoabdominal Aortic Aneurysm Repair

Elisabeth Zechendorf, Alexander Gombert, Tanja Bulow, Nadine Frank, Christian Beckers, Arne Peine, Drosos Kotelis, Michael J. Jacobs, Gernot Marx, Lukas Martin*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Acute kidney injury (AKI) is one of the most common post-operative complications and is closely associated with increased mortality after open and endovascular thoracoabdominal aortic aneurysm (TAAA) repair. Ribonuclease (RNase) 1 belongs to the group of antimicrobial peptides elevated in septic patients and indicates the prediction of two or more organ failures. The role of RNase 1 and its antagonist RNase inhibitor 1 (RNH1) after TAAA repair is unknown. In this study, we analyzed RNase 1 and RNH1 serum levels in patients undergoing open (n = 14) or endovascular (n = 19) TAAA repair to determine their association with post-operative AKI and in-hospital mortality. Increased RNH1 serum levels after open TAAA repair as compared with endovascular TAAA repair immediately after surgery and 12, 48, and 72 h after surgery (all p <0.05) were observed. Additionally, elevated RNase 1 and RNH1 serum levels 12, 24, and 48 h after surgery were shown to be significantly associated with AKI (all p <0.05). RNH1 serum levels before and RNase 1 serum levels 12 h after TAAA repair were significantly correlated with in-hospital mortality (both p <0.05). On the basis of these findings, RNase 1 and RNH1 may be therapeutically relevant and may represent biomarkers for post-operative AKI and in-hospital mortality.

Original languageEnglish
Article number3292
Number of pages13
JournalJournal of Clinical Medicine
Issue number10
Publication statusPublished - Oct 2020


  • thoracoabdominal aortic aneurysm
  • ribonuclease
  • ribonuclease inhibitor 1
  • biomarker
  • complex aortic surgery
  • acute kidney injury

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