The role of prostanoids in ozone-induced changes in airway responsiveness: receptor activation-specific prostanoid release.

H.J.M. Hoof; F.J. Zijlstra; H.P. Voss; C.J.A.M. Tak; L. van Bree; A. Bast

doi:10.1016/S1382-6689(97)10063-1

The role of prostanoids in ozone-induced changes in airway responsiveness: receptor activation-specific prostanoid release.

H.J.M. Hoof^*, F.J. Zijlstra, H.P. Voss, C.J.A.M. Tak, L. van Bree, A. Bast

^*Corresponding author for this work

NUTRIM School of Nutrition and Translational Research in Metabolism

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

We studied the effect of in vivo ozone exposure (3 ppm, 2 h) on methacholine- and histamine-induced guinea pig tracheal smooth muscle contractions in vitro and the role of cyclooxygenase products in this process. After exposure to ozone, methacholine stimulation showed a functional hyperreactivity, whereas after stimulation with histamine a hyporeactivity was observed. These effects could be explained by the release of prostanoids. In a control situation an increase in PGF2, PGE2 and PGD2 release is observed after stimulation of the histaminergic receptor system. After ozone exposure the release of prostanoids was also enhanced (unstimulated, PGF2 and TxB2; histamine, PGF2, PGE2; methacholine, PGF2, TxB2, 6-kPGF1, PGE2). This study shows that the prostanoid release is strongly dependent on the receptor system stimulated to induce smooth muscle contraction and the importance of prostanoids in ozone-induced changes in guinea pig tracheal smooth muscle reactivity.

Original language	English
Pages (from-to)	69-78
Number of pages	10
Journal	Environmental Toxicology and Pharmacology
Volume	5
Issue number	1
DOIs	https://doi.org/10.1016/S1382-6689(97)10063-1
Publication status	Published - 1 Jan 1998

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10.1016/S1382-6689(97)10063-1

Cite this

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title = "The role of prostanoids in ozone-induced changes in airway responsiveness: receptor activation-specific prostanoid release.",

abstract = "We studied the effect of in vivo ozone exposure (3 ppm, 2 h) on methacholine- and histamine-induced guinea pig tracheal smooth muscle contractions in vitro and the role of cyclooxygenase products in this process. After exposure to ozone, methacholine stimulation showed a functional hyperreactivity, whereas after stimulation with histamine a hyporeactivity was observed. These effects could be explained by the release of prostanoids. In a control situation an increase in PGF2, PGE2 and PGD2 release is observed after stimulation of the histaminergic receptor system. After ozone exposure the release of prostanoids was also enhanced (unstimulated, PGF2 and TxB2; histamine, PGF2, PGE2; methacholine, PGF2, TxB2, 6-kPGF1, PGE2). This study shows that the prostanoid release is strongly dependent on the receptor system stimulated to induce smooth muscle contraction and the importance of prostanoids in ozone-induced changes in guinea pig tracheal smooth muscle reactivity.",

author = "H.J.M. Hoof and F.J. Zijlstra and H.P. Voss and C.J.A.M. Tak and {van Bree}, L. and A. Bast",

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AU - Hoof, H.J.M.

AU - Zijlstra, F.J.

AU - Voss, H.P.

AU - Tak, C.J.A.M.

AU - van Bree, L.

AU - Bast, A.

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N2 - We studied the effect of in vivo ozone exposure (3 ppm, 2 h) on methacholine- and histamine-induced guinea pig tracheal smooth muscle contractions in vitro and the role of cyclooxygenase products in this process. After exposure to ozone, methacholine stimulation showed a functional hyperreactivity, whereas after stimulation with histamine a hyporeactivity was observed. These effects could be explained by the release of prostanoids. In a control situation an increase in PGF2, PGE2 and PGD2 release is observed after stimulation of the histaminergic receptor system. After ozone exposure the release of prostanoids was also enhanced (unstimulated, PGF2 and TxB2; histamine, PGF2, PGE2; methacholine, PGF2, TxB2, 6-kPGF1, PGE2). This study shows that the prostanoid release is strongly dependent on the receptor system stimulated to induce smooth muscle contraction and the importance of prostanoids in ozone-induced changes in guinea pig tracheal smooth muscle reactivity.

AB - We studied the effect of in vivo ozone exposure (3 ppm, 2 h) on methacholine- and histamine-induced guinea pig tracheal smooth muscle contractions in vitro and the role of cyclooxygenase products in this process. After exposure to ozone, methacholine stimulation showed a functional hyperreactivity, whereas after stimulation with histamine a hyporeactivity was observed. These effects could be explained by the release of prostanoids. In a control situation an increase in PGF2, PGE2 and PGD2 release is observed after stimulation of the histaminergic receptor system. After ozone exposure the release of prostanoids was also enhanced (unstimulated, PGF2 and TxB2; histamine, PGF2, PGE2; methacholine, PGF2, TxB2, 6-kPGF1, PGE2). This study shows that the prostanoid release is strongly dependent on the receptor system stimulated to induce smooth muscle contraction and the importance of prostanoids in ozone-induced changes in guinea pig tracheal smooth muscle reactivity.

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